Protective activity of processed tomato products on postprandial oxidation and inflammation: a clinical trial in healthy weight men and women

Molecular Nutrition & Food Research
Britt Burton-FreemanIndika Edirisinghe

Abstract

This study was designed to evaluate the ability of tomato rich in lycopene to modify postprandial oxidative stress, inflammation, and endothelial function in healthy weight individuals. Twelve women and 13 men (mean age = 27 ± 8 years; mean body mass index= 22 ± 2) consumed high-fat meals known to induce postprandial oxidative stress on two separate occasions containing either processed tomato product or non-tomato alternative. Blood samples were collected at 0, 30, 60, 90, 120 min, then hourly until 360 min. Flow-mediated dilation (FMD) was performed at 0 and 210 min. Endpoints included changes in glucose, insulin, lipids, oxidized low-density lipoprotein (OxLDL), inflammatory cytokines, and FMD. Both meals induced increases in plasma glucose, insulin, and lipid concentrations (p < 0.05). A trend for higher triglycerides at >240 min was observed after the tomato meal (p = 0.006). Tomato significantly attenuated high-fat meal-induced LDL oxidation (p < 0.05) and rise in interleukin-6 (p < 0.0001), a proinflammatory cytokine and inflammation marker. The data indicate that consuming tomato products with a meal attenuates postprandial lipemia-induced oxidative stress and associated inflammatory response. The relevance of OxLDL and...Continue Reading

References

May 1, 1992·The Journal of Experimental Medicine·R SchreckP A Baeuerle
Jun 28, 2000·Phytochemistry·P M Bramley
Oct 7, 2000·Journal of the American College of Nutrition·A V Rao, S Agarwal
Nov 18, 2000·Journal of the American College of Cardiology·R A VogelG D Plotnick
Jan 15, 2002·Journal of the American College of Cardiology·Mary C CorrettiUNKNOWN International Brachial Artery Reactivity Task Force
May 30, 2002·Biological Chemistry·Fulvio Ursini, Alex Sevanian
Nov 9, 2002·Experimental Biology and Medicine·David Heber, Qing-Yi Lu
Jul 4, 2003·The Journal of Nutrition·Howard D SessoJulie E Buring
Oct 4, 2003·Current Atherosclerosis Reports·Dianne HysonLars Berglund
Oct 4, 2003·Current Atherosclerosis Reports·Tom A B Sanders
Oct 16, 2004·Current Atherosclerosis Reports·Phyllis E Bowen, Gayatri Borthakur
Nov 9, 2004·The American Journal of Clinical Nutrition·Britt Burton-FreemanBarbara O Schneeman
May 4, 2005·The Journal of Nutrition·Helmut SiesAlex Sevanian
May 4, 2005·The Journal of Nutrition·Kirstie Canene-AdamsJohn W Erdman
Feb 14, 2006·The American Journal of Clinical Nutrition·Peter Libby
Mar 21, 2007·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Pia LundmanPer Tornvall
Jul 10, 2007·The British Journal of Nutrition·Marja-Leena SilasteSohvi Hörkkö
Jul 21, 2007·The British Journal of Nutrition·Karin JacobGaspar Ros Berruezo
Aug 12, 2008·Journal of the American College of Nutrition·Sridevi DevarajIshwarlal Jialal
Sep 26, 2008·Journal of Agricultural and Food Chemistry·Indika EdirisingheTissa Kappagoda
Dec 23, 2008·Cardiovascular Research·Kwang Kon KohMichael J Quon
Aug 21, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Dan FengRui-Dong Duan
Feb 26, 2010·Internal and Emergency Medicine·Gina BiasilloLuigi Marzio Biasucci
Jul 3, 2010·Journal of the American College of Nutrition·Britt Burton-FreemanTissa Kappagoda
Sep 16, 2010·Free Radical Biology & Medicine·Simone ReuterBharat B Aggarwal
May 6, 2011·The American Journal of Clinical Nutrition·Alastair B RossGary Williamson
Jul 9, 2011·The British Journal of Nutrition·Indika EdirisingheBritt M Burton-Freeman

❮ Previous
Next ❯

Citations

Sep 5, 2012·The British Journal of Nutrition·Guy VergèresMartin Gijs
Nov 24, 2012·Nutrition Research Reviews·Sébastien LacroixAnil Nigam
Apr 20, 2014·Mediators of Inflammation·Assunta RaiolaAmalia Barone
Aug 3, 2013·Vascular Pharmacology·Talya Wolak, Esther Paran
Feb 26, 2014·European Journal of Nutrition·Joanne R LuptonJohn Hathcock
May 29, 2014·Clínica e investigación en arteriosclerosis : publicación oficial de la Sociedad Española de Arteriosclerosis·Marijke A de VriesManuel Castro Cabezas
Jun 12, 2013·Canadian Journal of Physiology and Pharmacology·Thea MagroneMauro Serafini
Oct 22, 2016·Mechanisms of Ageing and Development·Giulia AccardiGiuseppina Candore
Feb 18, 2016·Oxidative Medicine and Cellular Longevity·Ivan M Petyaev
Mar 18, 2016·European Journal of Nutrition·J R LuptonJ C Griffiths
Jul 13, 2013·Molecular Nutrition & Food Research·Mohammed Herieka, Clett Erridge
Jun 19, 2013·Progress in Lipid Research·Kathleen M Botham, Caroline P D Wheeler-Jones
May 21, 2015·The British Journal of Nutrition·Alexandra SchmidGuy Vergères
Dec 17, 2014·Translational Research : the Journal of Laboratory and Clinical Medicine·Gemma VilahurLina Badimon
Feb 13, 2015·Critical Reviews in Food Science and Nutrition·Lars MüllerVolker Böhm
Dec 7, 2016·Maternal & Child Nutrition·Wilhelmenia L RossAmber Hromi-Fiedler
Jul 9, 2017·Molecular Nutrition & Food Research·Mariel Colmán-MartínezRosa M Lamuela-Raventós
Mar 22, 2019·Critical Reviews in Food Science and Nutrition·Montaña CámaraMachteld van Lieshout
Jan 26, 2018·Critical Reviews in Food Science and Nutrition·Ranga Rao AmbatiSu Yuepeng
Mar 13, 2018·Journal of the American College of Nutrition·Sedigheh AsgaryMahtab Keshvari
May 26, 2017·Anais Da Academia Brasileira De Ciências·Bernardita MonsalveEduardo Fuentes
Jun 8, 2018·Frontiers in Pharmacology·Ioana MozosAtanas G Atanasov
Apr 18, 2019·Nutrients·Sara Hurtado-BarrosoRosa M Lamuela-Raventós
Dec 8, 2020·Journal of Tissue Engineering·Yunqing XiangShuqiang Huang
Nov 3, 2020·Oxidative Medicine and Cellular Longevity·Natalia Di PietroCaterina Pipino

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.