PMID: 6404549Jan 1, 1983Paper

Protective activity of thymosin against opportunistic infections in animal models

Cancer Immunology, Immunotherapy : CII
H IshitsukaY Yagi

Abstract

Animal models for opportunistic infections were developed by using mice immunosuppressed by 5-FU. These mice were susceptible to various microorganisms, while normal mice had greater tolerance to such microbial infections. In these models, thymosin alpha 1 was found to protect mice against lethal infections with Candida albicans, Listeria monocytogenes, Pseudomonas aeruginosa, and Serratia marcescens when it was administered during 5-FU treatment prior to the infections. Thymosin alpha 1 was effective in some infections at 0.4-400 micrograms/kg/day IP, about 1/100 of the dose required for thymosin fraction 5. Activity was also demonstrated against L-monocytogenes and Ps. aeruginosa by counting the viable bacteria in the liver after infection. The protective activity against Candida, elimination of which macrophages were essential, was abrogated by anti-thymocyte serum and/or carrageenan, indicating that thymosin alpha 1 serves to maintain the functions of macrophages by reducing the damage to T cells by 5-FU. On the other hand, the activity against Pseudomonas infection was not affected by anti-thymocyte serum or carrageenan. It is probable that thymosin alpha 1 also exerts its effect on neutrophils without participation of T c...Continue Reading

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Citations

Jan 1, 1985·International Journal of Immunopharmacology·Y OhtaY Yagi
Jan 1, 1989·International Journal of Immunopharmacology·C FavalliE Garaci
Sep 1, 1994·International Journal of Immunopharmacology·J W Hadden
Dec 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J CaldarellaB L Horecker
Feb 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·A A HaritosB L Horecker
Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·A A HaritosB L Horecker
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·W H Eschenfeldt, S L Berger
Mar 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·T KomiyamaB L Horecker
Oct 12, 2012·Annals of the New York Academy of Sciences·Annalucia SerafinoEnrico Garaci
Nov 1, 1989·Clinical Immunology and Immunopathology·P G VlachoyiannopoulosO Tsolas
Aug 1, 2018·Expert Opinion on Biological Therapy·Na YangWeiqin Li
Apr 27, 2001·Immunopharmacology and Immunotoxicology·H OhmoriN Kanayama
Sep 27, 2019·Frontiers in Oncology·Claudio CostantiniLuigina Romani

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