Protective and therapeutic effects of sildenafil and tadalafil on aflatoxin B1-induced hepatocellular carcinoma.

Molecular and Cellular Biochemistry
Saurabh K ChhonkerRaj Kumar Koiri

Abstract

Hepatocellular carcinoma (HCC) has been classified as one of the most common forms of liver cancer occurring worldwide, and risk factors include hepatitis B & C virus, alcoholism, and dietary carcinogens like aflatoxin B1 (AFB1), which is produced by fungus Aspergillus flavus and Aspergillus parasiticus. Metabolism of AFB1 resulted into the formation of AFB1-exo-8, 9-epoxide which is largely responsible for HCC development. So far conventional cytotoxic chemotherapy has not provided much benefit in HCC, necessitating the need for newer treatment modalities. Recent reports suggest that phosphodiesterase-5 inhibitors (PDE5i) may have anticancer activity, but till date, the anticancer property of PDE5i (tadalafil & sildenafil) has not been evaluated in HCC. The present study was aimed to define the anticancer property of tadalafil and sildenafil against AFB1-induced HCC rats. Rats were randomly divided into five groups with five rats in each group. Except normal control group, rats of all other groups were fed with 5% alcohol via drinking water for 3 weeks. After 3 weeks, two successive dose of AFB1 (1 mg/kg bw, ip) was administered on subsequent days followed by the administration of PDE5i (tadalafil & sildenafil, 10 mg/kg bw) al...Continue Reading

References

Jan 1, 1990·Methods in Enzymology·H Esterbauer, K H Cheeseman
Nov 1, 1971·Analytical Biochemistry·C Beauchamp, I Fridovich
Aug 1, 1966·Analytical Biochemistry·Z A PlacerB C Johnson
Dec 1, 1995·The American Journal of Clinical Nutrition·H Sies, W Stahl
Nov 24, 1999·The Veterinary Quarterly·J Fink-Gremmels
Feb 27, 2003·The Journal of Cell Biology·Florian MullershausenDoris Koesling
May 1, 1959·Archives of Biochemistry and Biophysics·G L ELLMAN
Dec 28, 1964·Annals of the New York Academy of Sciences·B J DAVIS
Oct 7, 2004·Cancer Biology & Therapy·Niquiche Sangster-GuityPaulette McCormick
Dec 8, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Anamika Choudhary, R J Verma
Aug 27, 2005·Clinical and Experimental Pharmacology & Physiology·E O Farombi, I A Nwaokeafor
Oct 14, 2005·Kidney International·Bernardo Rodríguez-IturbeNosratola D Vaziri
Jun 2, 2007·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Raj Kumar KoiriLallan Mishra
Jun 16, 2007·Gastroenterology·Hashem B El-Serag, K Lenhard Rudolph
Jan 16, 2008·Archives of Environmental Contamination and Toxicology·C FernandesM A Salgado
Feb 13, 2008·World Journal of Urology·Azadeh BeheshtianAhmad Reza Dehpour
Feb 20, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sean F AltekruseMarsha E Reichman
Jul 17, 2009·The Kaohsiung Journal of Medical Sciences·Bulent ErolAydin Mungan
Oct 31, 2009·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Yurdal SerarslanTaşkin Yurtseven
Apr 8, 2010·Free Radical Research·Geou-Yarh Liou, Peter Storz
Jun 11, 2011·Toxicon : Official Journal of the International Society on Toxinology·Amal S HathoutMosaad A Abdel-Wahhab
Oct 14, 2011·The New England Journal of Medicine·Hashem B El-Serag
Apr 28, 2012·Gastroenterology·Hashem B El-Serag
May 30, 2012·Toxicology·Kerstin Gross-Steinmeyer, David L Eaton
Feb 24, 2015·Journal of Cellular Physiology·Mehrad TavallaiPaul Dent
Jun 1, 2013·Journal of Clinical and Experimental Hepatology·Mallikarjun PatilChannagiri K Adarsh
Dec 19, 2015·Oxidative Medicine and Cellular Longevity·Brajesh Kumar Maurya, Surendra Kumar Trigun
Jan 13, 2016·World Journal of Gastroenterology : WJG·Pei-Pei SongWei Tang
Jul 28, 2016·The Kaohsiung Journal of Medical Sciences·Sibel BektasSukru Oguz Ozdamar
Aug 9, 2016·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Feng GaoShu-Sen Zheng
May 4, 2017·Cancer Prevention Research·Sourav BhattacharyaRatna B Ray

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Methods Mentioned

BETA
X-ray
electrophoresis
PCR
MDA

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Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.