Protective and therapeutic effects of dexpanthenol on isoproterenol-induced cardiac damage in rats

Journal of Cellular Biochemistry
Ferhat KalkanAhmet Acet

Abstract

The purpose of the study was to explore the protective and therapeutic effects of dexpanthenol (DEX) on isoproterenol (ISO)-induced cardiac damage. Forty rats were distributed into four groups: group I (Control); group II (ISO); ISO (150 mg/kg/day) was given to rats once a day for 2 consecutive days with an interval of 24 h; group III (DEX+ISO): DEX (250 mg/kg) was applied 30 min before the first ISO administration and continued in the next two days after second ISO administration; group IV (ISO+DEX): After the ISO treatment at 1st and 2nd days, DEX was given at 3rd and 4th days. Rats were monitored for mean arterial blood pressure (BP), heart rate, oxygen saturation (%SO2 ), and electrocardiography (ECG). Heart tissue levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), reduced glutathione (GSH), total oxidant status (TOS); total antioxidant capacity (TAC), oxidative stress index (OSI), and caspase-3 were determined. BP and SO2 values indicated a significant decrease in the ISO group. Also, T wave negativity was observed in 6 of 10 rats, SOD, CAT, and GPX levels were significantly lower in ISO group than control group. ISO administration increased TOS and OSI levels, wherea...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Mar 10, 1969·The Journal of Vitaminology·Y AbikoM Shimizu
Jan 18, 1982·Life Sciences·J C Yeager, M E Whitehurst
Jan 1, 1995·Annual Review of Pharmacology and Toxicology·A W Harman, M J Maxwell
Jul 1, 1997·Mayo Clinic Proceedings·E V LoftusY Hasan
Jun 2, 1998·Free Radical Biology & Medicine·V S SlyshenkovL Wojtczak
Jul 13, 2002·American Journal of Clinical Dermatology·Fritz EbnerIrene Tausch
Apr 30, 2003·Experimental Physiology·David F GoldspinkLip-Bun Tan
Dec 24, 2004·Cell Biochemistry and Function·Engin SahnaAhmet Acet
Sep 1, 2005·Molecular and Cellular Biochemistry·Hakan ParlakpinarAhmet Acet
Oct 11, 2005·Clinical Biochemistry·Ozcan Erel
Apr 14, 2006·Molecular and Cellular Biochemistry·Yilmaz CigremisAhmet Acet
Aug 5, 2009·Thrombosis and Haemostasis·Sabine SteffensFrançois Mach
Nov 16, 2010·Human & Experimental Toxicology·Osman CiftciNevin Gurbuz
Jul 12, 2012·General Physiology and Biophysics·Zuzana NichtovaTatiana Stankovicova
Feb 8, 2013·Journal of Endourology·Ramazan AltintasHakan Parlakpinar
Sep 3, 2013·Naunyn-Schmiedeberg's Archives of Pharmacology·Hilal ErmisZeynep Ayfer Aytemur
Oct 11, 2013·Human & Experimental Toxicology·R AltintasZ R Duran
May 13, 2014·Therapeutic Advances in Cardiovascular Disease·Monika Garg, Deepa Khanna
Jul 19, 2014·Anadolu Kardiyoloji Dergisi : AKD = the Anatolian Journal of Cardiology·Selçuk İlhanEngin Şahna
Oct 3, 2014·Aging and Disease·Juliane SchulzeAlexander Dressel
Dec 10, 2015·The Libyan Journal of Medicine·Hasan Ali KirazFaruk Metin Çomu
Jan 1, 2011·Pharmaceuticals·Kazufumi NakamuraHiroshi Ito

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiotoxicity

Cardiotoxicity refers to the muscle damage or dysfunction of heart electrophysiology caused by drug intake or due to disease complications. It is a well-known side effect of several cytotoxic drugs, especially of the anthracyclines and can lead to long term morbidity. Here is the latest research.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Related Papers

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Isil Cakmak KaraerHakan Parlakpinar
Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission
S GedikE Altinoz
© 2022 Meta ULC. All rights reserved