Protective and toxic effects of a nuclease-resistant derivative of polyriboinosinic-polyribocytidylic acid on Venezuelan equine encephalomyelitis virus in rhesus monkeys

The Journal of Infectious Diseases
E L StephenR O Spertzel

Abstract

Polyriboinosinic-polyribocytidylic acid, stabilized with poly-L-lysine and carboxymethylcellulose (poly ICLC), favorably alters the pathogenesis of Venezuelan equine encephalomyelitis virus infection in rhesus monkeys by decreasing the number of infected monkey that become detectably viremic and by delaying the onset of viremia in the remaining monkeys. Poly ICLC is known to induce high circulating levels of interferon in primates, and the interferon system is assumed to be the mechanism by which poly ICLC exerts its antiviral effect. Poly ICLC treatment was associated with a few deaths, but only under certain conditions of infection and handling. The death of some infected, treated monkeys in the absence of death in monkeys that were either infected and untreated or treated and uninfected suggests a synergistic toxicity resulting from the combination of infection, handling, and poly ICLC treatment, although other explanations are possible.

Citations

Jan 1, 1981·Journal of Interferon Research·G P LampsonM R Hilleman
Aug 29, 2012·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Camila C DiasMarvin J Grubman
Mar 28, 2009·International Journal of Molecular Sciences·Mary E Christopher, Jonathan P Wong
May 14, 2005·Antiviral Chemistry & Chemotherapy·Michael Markosian, Robyn M Hyde

Related Concepts

Poly ICLC, sodium salt
Metazoa
Anthropoidea
Ruspol
Venezuelan equine encephalitis virus
Venezuelan Equine Encephalomyelitis
Females
Interferons
Macaca mulatta lasiota
Males

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