Protective aptitude of Periploca hydaspidis Falc against CCl4 induced hepatotoxicity in experimental rats

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Saima AliZartash Zahra

Abstract

In the present study the antioxidant capacity of Periploca hydaspidis was assessed through various in vitro assays and by the hepatoprotective potential on CCl4 induced toxicity in rat. Phytochemical analysis of different extracts of P. hydaspidis indicated existence of various phytochemical classes. HPLC-DAD analysis of methanol extract indicated the existence of rutin, gallic acid and caffeic acid. Total phenolic (TPC) and total flavonoid content (TFC) exhibited significant (p < 0.05) correlation with 1,1-diphenyl-2-picrylhydrazyl (DPPH), nitric oxide, hydroxyl ion, inhibition of β-carotene oxidation, iron chelation, reducing power and total antioxidant capacity. In hepatic sample of rat, CCl4 administration increased (p < 0.05) the level of nitrite, hydrogen peroxide (H2O2), thiobarbituric acid reactive substances (TBARS) whereas a decline was recorded in antioxidant enzymes; superoxide dismutase (SOD), peroxidase (POD), catalase (CAT) and in reduced glutathione (GSH). Concentration of alanine transaminase (ALT), alkaline phosphatase (ALP), aspartate transaminase (AST) and globulin increased (p < 0.05) whereas level of total protein and albumin decreased in serum of CCl4 treated rats. Level of pro-inflammatory cytokines; tum...Continue Reading

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Oct 4, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Saima AliMoniba Sajid

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Citations

Aug 1, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mingjin HuangYan Ren
Mar 6, 2019·Natural Product Research·Khadijah A JabalSabrin R M Ibrahim
Nov 26, 2019·Food Science & Nutrition·Guo-Kai WangJai-Sing Yang
Mar 24, 2021·Environmental Health and Preventive Medicine·Umbreen Rashid, Muhammad Rashid Khan
Apr 22, 2021·Microscopy Research and Technique·Saima AliRaees Khan

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