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Protective effect and mechanism of action of saponins isolated from the seeds of gac (Momordica cochinchinensis Spreng.) against cisplatin-induced damage in LLC-PK1 kidney cells

Bioorganic & Medicinal Chemistry Letters

Feb 4, 2016

Kiwon JungKi Hyun Kim

Abstract

This study was performed to investigate the renoprotective effect and mechanism of Momordicae Semen, gac seeds, against the cisplatin-induced damage in LLC-PK1 kidney cells. In order to identify the active components, three major saponins were isolated from extract of the gac seed, gyps...read more

Mentioned in this Paper

Saponin
Seminal Fluid
Study
Nephrotoxicity
Signaling Cascade
Apoptosis, Intrinsic Pathway
Mitogen-Activated Protein Kinases
Structure-Activity Relationship
Momordica
Omega-3 Fatty Acids
Paper Details
References

Protective effect and mechanism of action of saponins isolated from the seeds of gac (Momordica cochinchinensis Spreng.) against cisplatin-induced damage in LLC-PK1 kidney cells

Bioorganic & Medicinal Chemistry Letters

Feb 4, 2016

Kiwon JungKi Hyun Kim

PMID: 26838808

DOI: 10.1016/j.bmcl.2016.01.056

Abstract

This study was performed to investigate the renoprotective effect and mechanism of Momordicae Semen, gac seeds, against the cisplatin-induced damage in LLC-PK1 kidney cells. In order to identify the active components, three major saponins were isolated from extract of the gac seed, gyps...read more

Mentioned in this Paper

Saponin
Seminal Fluid
Study
Nephrotoxicity
Signaling Cascade
Apoptosis, Intrinsic Pathway
Mitogen-Activated Protein Kinases
Structure-Activity Relationship
Momordica
Omega-3 Fatty Acids

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Paper Details
References
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