Protective effect and mechanism of lycopene on endothelial progenitor cells (EPCs) from type 2 diabetes mellitus rats

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Yaochi ZengYa-Chi Zeng

Abstract

Endothelial progenitor cells (EPCs), widely existing in bone marrow and peripheral blood, are involved in the repair of injured vascular endothelium and angiogenesis which are important to diabetic mellitus (DM) patients with vascular complications. The number and the function of EPCs are related to the advanced glycation end products (AGEs) generated in DM patients. Lycopene (Lyc) is an identified natural antioxidant that protects EPCs under the microenvironment of AGEs from damage. However, the underlying mechanism remains unclear. To investigate the effect of Lyc on EPCs, we isolated EPCs from DM rat bone marrow and determined cell proliferation, cell cycle,apoptosis and autophagy of EPCs. The present study showed that 10μg/mL Lyc improved cell proliferation and had low cytotoxicity in the presence of AGEs. In addition, Lyc rescued S phase of the cell cycle arrest, reduced apoptosis rate and decreased autophagic reaction including ROS and mitochondrial membrane potential (MMP) of EPCs. Moreover, Lyc combined use of autophagy inhibitors, 3-MA, had better protective effects. Taken together, our data suggests that Lyc promotes EPCs survival and protect EPCs from apoptosis and oxidative autophagy induced by AGEs, further remaini...Continue Reading

References

Jul 1, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·C Garlanda, E Dejana
Jun 15, 2004·Prostate Cancer and Prostatic Diseases·N J Barber, J Barber
Aug 25, 2006·European Journal of Clinical Nutrition·A Basu, V Imrhan
Jan 17, 2009·Scandinavian Journal of Clinical and Laboratory Investigation·Mamdouh M Ali, Fatma G Agha
Sep 30, 2010·The Journal of Biological Chemistry·Yan DingMary E Choi
Nov 30, 2010·Biochemical and Biophysical Research Communications·Yunxia ZhuXiao Han
Feb 22, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Alan R KristalIan M Thompson
Aug 30, 2012·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Marco F LombardoGiuseppe Irrera
Oct 12, 2012·The American Journal of Clinical Nutrition·Xiang-Dong Wang
Aug 1, 2014·International Journal of Medical Sciences·Simone ElgassMridula Chopra
Mar 19, 2015·Biomolecules·Kerstin NowotnyTilman Grune
Jun 27, 2015·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G-Y BanH-S Park
Feb 14, 2016·Biochemical and Biophysical Research Communications·Kan SunMeng Ren

❮ Previous
Next ❯

Citations

May 5, 2018·Stroke; a Journal of Cerebral Circulation·Kyeong-A KimOk-Nam Bae
Jun 8, 2018·Frontiers in Pharmacology·Ioana MozosAtanas G Atanasov
Oct 21, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lucia MorbidelliSandra Donnini
Aug 8, 2020·Antioxidants·Muhammad ImranMaksim Rebezov
Mar 23, 2018·Acta Biochimica Et Biophysica Sinica·Weishuai LianMaoquan Li
Apr 11, 2019·Frontiers in Cardiovascular Medicine·Shahida ShafiSihem Aouabdi
Feb 26, 2019·Oxidative Medicine and Cellular Longevity·Rongzi LiJeganathan Ramesh Babu
Aug 19, 2020·International Journal of Molecular Sciences·Suyun Choi, Hyeyoung Kim
Sep 29, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Ingrid Delbone FigueiredoAmanda Martins Baviera
Jun 15, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ruyuan ZhuDongwei Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Related Papers

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Yi ZhanDe-hong Cai
Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih
Yi-Jun ZhouJin Zhang
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Ming-Hua ZhangXiao-Bin Jia
© 2022 Meta ULC. All rights reserved