Protective effect and mechanism of rebamipide on NSAIDs associated small bowel injury.

International Immunopharmacology
Ning XuZhenhai Yu

Abstract

To investigate the protective effect and mechanism of rebamipide on NSAIDs associated intestinal injury. Intestinal injury was induced in Sprague Dawley rats by intragastric administration of diclofenac with rebamipide intervention, and LPS and TAK-242 were given intraperitoneally respectively. The expression of TLR4/NF-κB and the related proteins in the intestinal mucosa were detected. 55 patients taking NSAIDs and diagnosed as NSAIDs associated small intestinal injury were recruited as NSAIDs group. Another 55 patients without NSAIDs and no obvious abnormality in the small bowel served as the control group. The macroscopic and histological scores of the small intestinal mucosa in the rebamipide pretreatment group were significantly lower compared to the diclofenac group (p < 0.01). The expressions of Tollip, ZO-1 and Claudin-1 in the diclofenac group were down-regulated compared with that in the control group, while they increased significantly in the rebamipide pretreatment group (p < 0.01). The expressions of TLR4/NF-κBp65, IL-1β, IL-6, IL-8, and TNF-α significantly increased in the model group while they were down-regulated in the rebamipide pretreatment group (p < 0.05). Administration of LPS 1 h after diclofenac aggravat...Continue Reading

References

Nov 1, 1996·The Journal of Clinical Investigation·B K ReuterJ L Wallace
Aug 18, 1999·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·J BergD Stimmeder
Nov 1, 2001·Journal of Gastroenterology and Hepatology·H MizoguchiK Takeuchi
Jul 4, 2007·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·R MuraiG Shiota
Nov 23, 2007·Biochemical Society Transactions·M Fukata, M T Abreu
Dec 7, 2010·European Journal of Pharmacology·Tomohisa IwaiKazuhiko Ishihara
Mar 5, 2011·Journal of Clinical Biochemistry and Nutrition·Naotaka OgasawaraKunio Kasugai
Mar 15, 2012·World Journal of Gastroenterology : WJG·Lei DiaoMo-Li Chen
Oct 2, 2012·Journal of Gastroenterology and Hepatology·Shinya YamadaToshikazu Yoshikawa
Oct 24, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Urs A BoelsterliKyle S Saitta
Mar 14, 2013·Investigative Ophthalmology & Visual Science·Kazuhiro KimuraKoh-Hei Sonoda
Feb 26, 2014·Journal of Crohn's & Colitis·Evangelina Terán-VenturaVicente Martínez
May 21, 2017·Toxicology and Applied Pharmacology·Sehwan ShimSunhoo Park
Oct 20, 2017·Journal of Gastroenterology and Hepatology·Hyosun JangSehwan Shim
Nov 21, 2017·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Nastaran KordjazyAmir Hossein Abdolghaffari
Dec 2, 2017·Digestive Diseases and Sciences·Mohamed Hasif JaafarSanjiv Mahadeva
Feb 14, 2018·Current Opinion in Gastroenterology·Foong Way David Tai, Mark E McAlindon
Dec 23, 2019·Journal of Gastroenterology·Toshio WatanabeFrancis K L Chan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Dustin L CooperSam Harirforoosh
Nihon rinsho. Japanese journal of clinical medicine
Tadashi ShimoyamaKazuo Sugawara
© 2021 Meta ULC. All rights reserved