Protective effect of a 21-aminosteroid on the blood-brain barrier following subarachnoid hemorrhage in rats

Stroke; a Journal of Cerebral Circulation
M Zuccarello, D K Anderson

Abstract

The effects of subarachnoid injection of blood on blood-brain barrier permeability to albumin was assessed in a rat model. Subarachnoid injection of blood caused a significant sixfold increase in Evans blue extravasation, whereas sham operation or NaCl injection had no effect. In addition, subarachnoid injections of arachidonic acid or FeCl2 increased blood-brain barrier permeability to Evans blue 16- and 10-fold, respectively. The capillary permeability after subarachnoid injection of blood was normalized by pretreatment with a novel 21-aminosteroid, U-74006F, that has antioxidant and antilipolytic activity. Pretreatment with U-74006F also reduced the vascular leakage induced by subarachnoid injection of arachidonic acid or FeCl2 by 50% and 45%, respectively. We conclude that damage to membrane lipids by peroxidative and/or lipolytic processes is involved in the subarachnoid hemorrhage-induced blood-brain barrier opening and that U-74006F protects the blood-brain barrier against the effects of subarachnoid hemorrhage by preventing or limiting these pathologic membrane lipid changes.

References

Oct 1, 1986·The American Journal of Physiology·E P WeiJ T Povlishock
Feb 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S A Lang, M B Maron
Feb 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S SakakiS Takeda
Jan 1, 1988·Acta neurochirurgica·M ZuccarelloM Yamashita
Jul 1, 1985·Stroke; a Journal of Cerebral Circulation·N F KassellG Nazar
Jan 1, 1980·Neurological Research·K SanoT Sasaki
Jun 1, 1984·Journal of Neurosurgery·T SasakiN F Kassell
Jan 1, 1982·Acta neurochirurgica·T Trojanowski

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Citations

Dec 1, 1995·Journal of the Neurological Sciences·E D Hall
Aug 1, 1994·Journal of Neurotrauma·S W HoffmanD G Stein
Dec 1, 1994·Journal of Neurotrauma·M ZuccarelloD K Anderson
Feb 1, 1993·Neurosurgery·S TakahashiK S Lee
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·C DenisD D Wagner
May 1, 1997·Molecular and Chemical Neuropathology·R L RoofD G Stein
Sep 29, 2001·British Journal of Anaesthesia·R J Kavanagh, P C Kam
Sep 15, 1995·Annals of the New York Academy of Sciences·G C PalmerF Willett
Nov 22, 2011·World Neurosurgery·Robert G WhitmoreSherman C Stein
Sep 15, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Gen KusakaJohn H Zhang
Oct 12, 2012·Thrombosis and Haemostasis·Annette von DrygalskiJohn H Griffin
Mar 1, 1992·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S T OhnishiR Ogawa
Jun 1, 1993·Annals of Emergency Medicine·E D Hall
Mar 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A M BuchanH Li
Jul 12, 2018·Translational Neuroscience·Duo ChenJun-Hong Guan
May 1, 1990·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·R F Del MaestroC L Farrell

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