Protective effect of a marine oligopeptide preparation from chum salmon (Oncorhynchus keta) on radiation-induced immune suppression in mice

Journal of the Science of Food and Agriculture
Ruiyue YangYong Li

Abstract

A marine oligopeptide preparation (MOP) obtained from Chum Salmon (Oncorhynchus keta) by the method of enzymatic hydrolysis, has been found to enhance the innate and adaptive immunities through stimulation of the secretion of cytokines in mice. The current study aimed to further investigate the protective effect of MOP on radiation-induced immune suppression in mice. Female ICR mice (6-8 weeks old) were randomly divided into three groups, i.e. blank control, irradiation control and MOP (1.350 g kg(-1) body weight) plus irradiation-treated group. MOP significantly increased the survival rate and prolonged the survival times for 30 days after irradiation, and lessened the radiation-induced suppression of T- or B-lymphocyte proliferation, resulting in the recovery of cell-mediated and humoral immune functions. This effect may be produced by augmentation of the relative numbers of radioresistant CD(4) (+) T cells, enhancement of the level of immunostimulatory cytokine, IL-12, reduction of the level of total cellular NF-κB through the induction of IκB in spleen and inhibition of the apoptosis of splenocytes. We propose that MOP be used as an ideal adjuvant therapy to alleviate radiation-induced injuries in cancer patients.

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Citations

Dec 20, 2012·International Journal of Environmental Research and Public Health·Zi-Luan FanShuang-Qi Tian
Jan 21, 2012·Journal of Food Science·Chibuike C Udenigwe, Rotimi E Aluko
Nov 14, 2015·Critical Reviews in Food Science and Nutrition·Blanca Hernández-Ledesma, Chia-Chien Hsieh
Mar 5, 2016·Journal of the Science of Food and Agriculture·Lourdes Santiago-LópezAarón F González-Córdova
Aug 10, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hua ZhangZhiqiang Xia
Sep 2, 2021·Journal of Food Biochemistry·Somnath Basak, Jyoti Gokhale

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