PMID: 6988605May 1, 1980Paper

Protective effect of a splenic extract in mice with endotoxemia

The Journal of Trauma
C R SpillertK M Jain

Abstract

We have previously described the isolation of a lipoidal splenic extract (LSE) that demonstrated a variety of hematologic effects including inhibition of platelet aggregation both in vivo and in vitro. Since endotoxin causes platelet aggregation and microembolism the protective effect of LSE in endotoxemia was examined in the present study. Both young and elderly Swiss mice given LSE 2--3 hours before endotoxin challenge showed a statistically significant increase in survival compared with saline-treated controls. However, no significant improvement in survival was noted when LSE was administered at the same time as endotoxin. These results add further support to the role of the spleen in the control of infection.

Citations

Oct 17, 1981·British Medical Journal·G K Scadding, C W Havard

Related Concepts

Ivy Method
Endotoxins
Alkalescens-Dispar Group
Structure of Mesenteric Vein
Spleen
Tissue Extracts
Septic Toxemia

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