Abstract
The antiarrhythmic effects of captopril, a sulphydryl-containing angiotensin converting enzyme (ACE) inhibitor, were compared with those of the nonsulphydryl-containing ACE inhibitor lisinopril and the sulphydryl-containing agent glutathione in an in vivo rat model of coronary artery ligation. To produce arrhythmia, the left main coronary artery was occluded for 7 min, followed by 7 min of reperfusion. Captopril (3 mg kg-1) and lisinopril (0.1, 0.3 or 1 mg kg-1) caused marked decreases in mean arterial blood pressure (BP) and heart rate, whereas glutathione (5 mg kg-1) had no effect on them. The incidence of ventricular tachycardia (VT) on ischemia and reperfusion was significantly reduced by captopril and lisinopril. Captopril and 1 mg kg-1 lisinopril also significantly decreased the number of VEB during occlusion and the duration of VT on reperfusion, respectively. These drugs also attenuated the incidence of reversible ventricular fibrillation (VF) and the number of ventricular ectopic beats (VEB) during reperfusion. However, glutathione only reduced the incidence of VT on reperfusion, significantly. These results suggest that, in this experimental model, ACE inhibitors limit the arrhythmias following ischemia-reperfusion an...Continue Reading
References
Jan 1, 1992·Journal of Cardiovascular Pharmacology·W Linz, B A Schölkens
Aug 1, 1991·Circulation Research·A T HirschV J Dzau
Feb 1, 1991·Journal of Cardiovascular Pharmacology·J E KoernerR C Dage
Feb 1, 1992·Hypertension·V CachofeiroA Nasjletti
Jan 1, 1991·European Journal of Applied Physiology and Occupational Physiology·P L GreenhaffM Dunnett
Sep 30, 1991·The American Journal of Medicine·R FerrariO Visioli
Dec 1, 1990·Biochemical Society Transactions·M ChopraW E Smith
Aug 1, 1990·Cardiovascular Drugs and Therapy·D J Hearse
Apr 1, 1990·European Heart Journal·J van WijngaardenH Wesseling
Feb 1, 1990·Cardiovascular Research·W A CoetzeeL H Opie
Jan 1, 1987·Journal of Cardiovascular Pharmacology·P A de GraeffH Wesseling
Jul 18, 1989·European Journal of Pharmacology·L Carlsson, T Abrahamsson
Mar 1, 1986·Circulation Research·M BernierA S Manning
Jul 1, 1988·Cardiovascular Research·M J WalkerD W Harron
Nov 1, 1987·British Journal of Pharmacology·M W RadomskiS Moncada
Jun 30, 1988·Biochimica Et Biophysica Acta·A ArduiniF Cuccurullo
Jun 1, 1984·Journal of Molecular and Cellular Cardiology·A S Manning, D J Hearse
Jun 1, 1993·Journal of Cardiovascular Pharmacology·J C HartmanR J Shebuski
Jul 1, 1994·European Heart Journal·J H KingmaR P Wielenga
Jul 1, 1994·European Heart Journal·C A MullerC A Pineda
Jan 1, 1996·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·A B Iskit, M O Guc
Citations
May 24, 2005·Regulatory Peptides·Nermina JahovicInci Alican
Aug 26, 2000·Clinica Chimica Acta; International Journal of Clinical Chemistry·V B PatelV R Preedy
Jul 20, 2000·Clinica Chimica Acta; International Journal of Clinical Chemistry·D MantleV R Preedy
Feb 28, 2002·British Journal of Pharmacology·G F Baxter, Z Ebrahim
Sep 16, 2003·Critical Care Medicine·Manuel Ruiz-BailénUNKNOWN ARIAM Group
Sep 9, 2005·Cell Biochemistry and Function·Zeliha Selamoglu Talas, Muhittin Yurekli
May 16, 2006·Experimental Eye Research·Iliyana IlievaShigeaki Ohno
Apr 3, 2007·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Hakan AydoganAhmet Acet
Apr 22, 2004·The Journal of Pharmacy and Pharmacology·Silvia ButzChristian E Zaugg
Oct 18, 2000·Toxicology and Applied Pharmacology·A M Agha, M Mansour
Jan 15, 2016·PloS One·Mortimer GierthmuehlenDennis T T Plachta