PMID: 11917207Mar 28, 2002Paper

Protective effect of acetaminophen against colon cancer initiation effects of 3,2'-dimethyl-4-aminobiphenyl in rats

European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)
G M WilliamsT Shirai

Abstract

A previous investigation demonstrated the anticarcinogenicity of acetaminophen (APAP) against colon carcinogenesis in rats induced by 3,2'-dimethyl-4-aminobiphenyl (DMAB). DMAB was selected as a structurally related surrogate for heterocyclic amines, formed during cooking of protein, which are believed to be involved in human colon cancer. The objective of the present study was to ascertain whether the early initiating effects of this colon carcinogen are inhibited by APAP. Six groups of male F344 rats were treated over a 6-week period as follows: (1) vehicle (corn oil) for 6 weeks; (2) APAP in the diet at 1000 ppm daily for 6 weeks; (3) 50 mg/kg DMAB by gavage once a week for the last 4 weeks; (4) 5 mg/kg DMAB as for (3); (5) 1000 ppm APAP for 6 weeks and 50 mg/kg DMAB for the last 4 weeks; and (6) 1000 ppm APAP and 5 mg/kg DMAB as for (5). Colonic tissue was within normal limits in the control and APAP groups. In the APAP only group, apical enterocytic hypertrophy and hyperaemia over the entire surface epithelium was present. In the high-dose DMAB group, in the lower third of the crypts, foci of enlarged glands with hypertrophic cells exhibiting karyomegaly and anisokaryosis (FHE) of 3+ degree of severity were evident in 100%...Continue Reading

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Citations

Dec 21, 2006·Toxicologic Pathology·Alan M JeffreyGary M Williams
Dec 25, 2007·Experimental Biology and Medicine·Yi FengDavid W Hein
Jan 20, 2009·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Małgorzata M PosmykRenata Kontek
Apr 17, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Gary M WilliamsJian-Dong Duan
Dec 21, 2006·Journal of Cosmetic Dermatology·J L O'Donoghue
Dec 20, 2007·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Gary M WilliamsCarmen E Perrone
Jan 22, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S T RashidA M Seifalian
May 1, 2021·Veterinary Sciences·Elisabete Nascimento-GonçalvesPaula A Oliveira

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