PMID: 3025567Jan 1, 1986Paper

Protective effect of acidic mannan fraction of bakers' yeast on experimental candidiasis in mice

Microbiology and Immunology
Y OkawaM Suzuki

Abstract

An acidic fraction of bakers' yeast mannan, WAM025, showed a significant protective effect against Candida albicans infection in mice, but a neutral fraction of the same bakers' yeast mannan, WNM, did not exhibit this effect. Moreover, pretreatment with WAM025 resulted in a marked reduction of proliferation of C. albicans cells in the organs of the infected mice. We investigated the stimulative effect of these mannan fractions on the function of mouse peritoneal phagocytes, and found that mice administered WAM025 showed a greater increase in the number of peritoneal exudate cells, macrophages and polymorphonuclear leucocytes (PMN), than the mice treated with WNM, especially in the proportion of PMN. Peritoneal phagocytes, PMN and macrophages obtained from WAM025-treated mice showed marked candidacidal activity. Of the phagocytes, PMN were responsible for the larger part of the candidacidal activity. The myeloperoxidase activities of PMN and macrophages in WAM025-treated PEC were greater than in untreated macrophages. The myeloperoxidase activity of WAM025-treated PMN was significantly greater than that of WAM025-treated macrophages. This activity paralleled the active oxygen-releasing activity of the phagocytes. On the other ha...Continue Reading

References

Jan 1, 1979·Microbiology and Immunology·A ShiraishiT Arai
Feb 1, 1985·Infection and Immunity·C D Wright, R D Nelson
May 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·T Z LiuW F Ganong
Jan 1, 1984·Microbiology and Immunology·K SuzukiM Suzuki
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Jan 1, 1984·Microbiology and Immunology·T NagaseM Suzuki
Mar 1, 1980·Infection and Immunity·A E Hilger, D L Danley

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Citations

Feb 1, 1989·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M ItoE De Clercq
Jan 1, 1990·Microbiology and Immunology·M KobayashiM Suzuki
Mar 1, 1990·Japanese Journal of Cancer Research : Gann·K TsukadaM Suzuki
Oct 6, 2007·Biological & Pharmaceutical Bulletin·Yoshio OkawaHidemitsu Kobayashi
Jan 1, 1989·Critical Reviews in Microbiology·J E Domer
May 11, 2004·Biological & Pharmaceutical Bulletin·Yoshio OkawaMasuko Suzuki
Aug 2, 2008·Biological & Pharmaceutical Bulletin·Yoshio OkawaHidemitsu Kobayashi
Jul 28, 2020·Journal of Fungi·Man Shun Fu, Rebecca A Drummond
May 31, 2018·Seminars in Cell & Developmental Biology·Jessica Quintin
Mar 17, 1997·Biochemical and Biophysical Research Communications·W T TanakaT Matsumoto

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