PMID: 14672760Dec 16, 2003

Protective effect of acteoside on carbon tetrachloride-induced hepatotoxicity

Life Sciences
Kyung Jin LeeHye Gwang Jeong

Abstract

This study investigated the protective effects of acteoside, a phenylethanoid glycoside, on the carbon tetrachloride-induced hepatotoxicity as well as the possible mechanisms involved in this protection in mice. Pretreatment with acteoside prior to the administration of carbon tetrachloride significantly prevented the increased serum enzymatic activities of alanine and aspartate aminotransferase in a dose-dependent manner. In addition, pretreatment with acteoside significantly prevented the increase in hepatic malondialdehyde formation and the depletion of the reduced glutathione content in the liver of carbon tetrachloride-intoxicated mice. Carbon tetrachloride-induced hepatotoxicity was also essentially prevented, as indicated by a liver histopathologic study. The effects of acteoside on cytochrome P450 (P450) 2E1, the major isozyme involved in carbon tetrachloride bioactivation were also investigated. Treatment of the mice with acteoside resulted in a significant decrease in the P450 2E1-dependent pnitrophenol and aniline hydroxylation in a dose-dependent manner. Consistent with these observations, the P450 2El protein levels were also lower. Acteoside exhibited anti-oxidant effects on FeCl2-ascorbate induced lipid peroxidat...Continue Reading

References

Mar 1, 1991·Chemical Research in Toxicology·F P GuengerichM Iwasaki
Nov 1, 1990·Seminars in Liver Disease·A T Williams, R F Burk
Jan 1, 1989·Pharmacology & Therapeutics·R O RecknagelR L Waller
Jan 1, 1985·Journal of Free Radicals in Biology & Medicine·W J BrattinR O Recknagel
Aug 1, 1984·Journal of Ethnopharmacology·P J Houghton
Jan 1, 1982·Toxicology·S FairhurstA A Horton
May 1, 1994·Free Radical Biology & Medicine·F UrsiniG Pifferi
May 17, 1996·The Journal of Biological Chemistry·S S LeeF J Gonzalez
Jun 21, 2001·Journal of Agricultural and Food Chemistry·I Y WongZ Y Chen

Citations

Nov 28, 2007·Archives of Pharmacal Research·Yong Pil HwangHye Gwang Jeong
Mar 9, 2005·Biochemical and Biophysical Research Communications·Ying-Shan JinMyeong-Hyeon Wang
May 3, 2011·Journal of Asian Natural Products Research·Jiang HeZhen-Dan He
Nov 26, 2009·The American Journal of Chinese Medicine·Hiroshi ShimodaMuh-Hwan Su
Jan 6, 2009·Biological & Pharmaceutical Bulletin·Hai Ming ShiXiao Bo Li
Nov 2, 2011·Biological & Pharmaceutical Bulletin·Ju-Feng YeBing-De Luo
Dec 21, 2010·International Journal of Ayurveda Research·Rumi GhoshVilasrao J Kadam
Sep 26, 2014·Journal of Natural Medicines·Gabriela Pérez-BarrónAntonio Monroy-Noyola
Apr 5, 2016·Pharmacognosy Reviews·Uorakkottil IlyasPunnooth Poonguzi Naseef
May 21, 2011·Pharmaceutical Biology·Nilanjan GhoshSubhash C Mandal
Oct 18, 2011·Drug and Chemical Toxicology·Sinan InceIsmail Kucukkurt
Jan 1, 2014·Antioxidants·Dharmendra SinghRadhey Shyam Gupta
May 29, 2012·Biochemical and Biophysical Research Communications·Entsar A Saad
Dec 25, 2015·Toxicology and Applied Pharmacology·Young-Suk WonHyo-Jung Kwon
Jul 12, 2011·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Li LiYong Woo Lee
Aug 18, 2010·Toxicology and Applied Pharmacology·Hyo-Jung KwonHyoung-Chin Kim
Oct 20, 2009·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Jishu QuanHuixian Xu
Nov 21, 2009·Chemistry and Physics of Lipids·Lorena FunesVicente Micol
Nov 6, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yong Pil HwangHye Gwang Jeong
Jun 26, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Kyung Jin LeeHye Gwang Jeong
Jun 23, 2005·The Journal of Pharmacy and Pharmacology·Jae Wook OhKeon Wook Kang
Sep 1, 2012·Toxicological Research·Sang Wha LeeWol-Soon Jo
Mar 31, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Andrew H WuHaichao Wang
Dec 19, 2009·Evidence-based Complementary and Alternative Medicine : ECAM·Lizhi XuZhong-Ming Qian
Jul 22, 2010·Pharmaceutical Biology·Shemsu UmerCiddi Veeresham
Feb 24, 2015·Chinese Medicine·Nurul Elyani MohamadNoorjahan Banu Alitheen
Dec 27, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·QuanFang HuangXing Lin
Apr 24, 2013·Asian Pacific Journal of Tropical Medicine·Amel M SolimanGamiaa A Alswiai
Aug 9, 2016·Medicinal Chemistry Research : an International Journal for Rapid Communications on Design and Mechanisms of Action of Biologically Active Agents·Faraz Shaikh, Shirley W I Siu
Sep 27, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Kristina BljajićMarijana Zovko Končić
Sep 13, 2016·International Journal of Biological Macromolecules·Yin WanGuiming Fu
Apr 30, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kristina BljajićMarijana Zovko Končić
Apr 6, 2018·Biological & Pharmaceutical Bulletin·Shun GuoYan Zhang
Nov 30, 2007·The Journal of Gene Medicine·Chi ZhangJunchuan Qin
Jun 20, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anna-Mari ReidNamrita Lall
Nov 9, 2016·Journal of Basic and Clinical Physiology and Pharmacology·Ifeoluwa T OyeyemiAdekunle A Bakare
Aug 18, 2018·Oxidative Medicine and Cellular Longevity·G CorbiD Casamassima
Jun 21, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Shashi Kant VermaMohd Samim
Jul 12, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Abeer H ElmaidomyHossam M Hassan
Aug 4, 2020·Chemical & Pharmaceutical Bulletin·Huibo LeiWeidong Zhang
Jan 22, 2019·International Journal of Molecular Medicine·Tae Woong HwangJwa-Jin Kim
Jul 2, 2019·Chemical & Pharmaceutical Bulletin·Toshio MorikawaOsamu Muraoka

Related Concepts

Ferric chloride, 59Fe-labeled cpd
Acteoside
SGPT - Glutamate pyruvate transaminase
Antioxidant Effect
Magnorbin
SGOT - Glutamate oxaloacetate transaminase
Toxic Effect of Carbon Tetrachloride
Chloride Ion Level
Dose-Response Relationship, Drug
Ferric Compounds

Related Feeds

Cardiac Glycosides

Cardiac glycosides are a diverse family of naturally derived compounds that bind to and inhibit na+/k+-atpase. Discover the latest research on cardiac glycosides heres.