Protective effect of agaro-oligosaccharides on gut dysbiosis and colon tumorigenesis in high-fat diet-fed mice

American Journal of Physiology. Gastrointestinal and Liver Physiology
Yasuki HigashimuraToshikazu Yoshikawa

Abstract

High-fat diet (HFD)-induced alteration in the gut microbial composition, known as dysbiosis, is increasingly recognized as a major risk factor for various diseases, including colon cancer. This report describes a comprehensive investigation of the effect of agaro-oligosaccharides (AGO) on HFD-induced gut dysbiosis, including alterations in short-chain fatty acid contents and bile acid metabolism in mice. C57BL/6N mice were fed a control diet or HFD, with or without AGO. Terminal restriction fragment-length polymorphism (T-RFLP) analysis produced their fecal microbiota profiles. Profiles of cecal organic acids and serum bile acids were determined, respectively, using HPLC and liquid chromatography-tandem mass spectrometry systems. T-RFLP analyses showed that an HFD changed the gut microbiota significantly. Changes in the microbiota composition induced by an HFD were characterized by a decrease in the order Lactobacillales and by an increase in the Clostridium subcluster XIVa. These changes of the microbiota community generated by HFD treatment were suppressed by AGO supplementation. As supported by the data of the proportion of Lactobacillales order, the concentration of lactic acid increased in the HFD + AGO group. Data from th...Continue Reading

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Citations

Jan 24, 2019·The British Journal of Nutrition·Rafael Oliveira PinheiroJailane de Souza Aquino
Feb 13, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yogesh Bhattarai, Purna C Kashyap
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Oct 6, 2017·Journal of Nutritional Science and Vitaminology·Yasuki HigashimuraYuji Naito
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May 4, 2021·Critical Reviews in Food Science and Nutrition·Xu-Ting Xie, Kit-Leong Cheong
Jun 24, 2017·Microbiology Spectrum·Terence Van Raay, Emma Allen-Vercoe

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