Protective Effect of All-Trans Retinoic Acid in Cisplatin-Induced Testicular Damage in Rats

The World Journal of Men's Health
Cem YucelZafer Kozacioglu

Abstract

To investigate the effects of all-trans retinoic acid (ATRA) in cisplatin (CP)-induced testicular damage in rats. Twenty-eight male Wistar rats were divided into four groups: Control, ATRA alone, ATRA+CP, and CP alone. Body weight, testicular weight, sperm count, sperm motility, percentage of abnormal sperm, total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI) in testicular tissue, and testicular histopathology were compared among groups. The sperm count and motility significantly decreased and the percentage of abnormal sperm significantly increased in the CP group compared to the control and ATRA groups. CP+ATRA administration significantly increased the sperm count and motility, but reduced the abnormal sperm count. CP administration significantly increased TOS and OSI compared to the control group and the other groups. Administering CP+ATRA significantly decreased TOS and the OSI in testicular tissue and reduced spermatogenesis, but increased the Johnsen score. The destructive effects of CP treatment on testicular tissue and spermatogenesis were reduced by administering ATRA.

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Citations

Mar 25, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Basel A Abdel-WahabEmad H M Hassanein
Apr 2, 2021·Environmental Science and Pollution Research International·Emad H M HassaneinSouty M Z Sharkawi
Jun 24, 2021·Dose-response : a Publication of International Hormesis Society·Muhammad Umar IjazHaseeb Anwar
Jul 3, 2021·International Journal of Molecular Sciences·Yeon Ju KimYun-Hoon Choung
Nov 26, 2021·Journal of Biochemical and Molecular Toxicology·Atena RahimiZahra Memariani

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Methods Mentioned

BETA
light microscopy
Assay

Software Mentioned

Statistical Package for the Social Science

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