Protective effect of alpha-lipoic acid against ischaemic acute renal failure in rats

Clinical and Experimental Pharmacology & Physiology
Masanori TakaokaYasuo Matsumura

Abstract

1. In the present study, we investigated whether treatment with alpha-lipoic acid (LA), a powerful and universal anti-oxidant, has renal protective effects in rats with ischaemic acute renal failure (ARF). 2. Ischaemic ARF was induced by occlusion of the left renal artery and vein for 45 min followed by reperfusion, 2 weeks after contralateral nephrectomy. Blood urea nitrogen (BUN), plasma concentrations of creatinine (Pcr) and urinary osmolality (Uosm) were measured for the assessment of renal dysfunction. Creatinine clearance (Ccr) and fractional excretion of Na+ (FENa) were used as indicators of glomerular and tubular function, respectively. 3. Renal function in ARF rats decreased markedly 24 h after reperfusion. Intraperitoneal injection of LA at a dose of 10 mg/kg before the occlusion tended to attenuate the deterioration of renal function. A higher dose of LA (100 mg/kg) significantly (P < 0.01) attenuated the ischaemia/reperfusion-induced increases in BUN (19.1 +/- 0.7 vs 7.2 +/- 0.7 mmol/L before and after treatment, respectively), Pcr (290 +/- 36 vs 78.1 +/- 4.2 micromol/L before and after treatment, respectively) and FENa (1.39 +/- 0.3 vs 0.33 +/- 0.09% before and after treatment, respectively). Treatment with 100 mg/...Continue Reading

References

May 1, 1992·The Journal of Experimental Medicine·R SchreckP A Baeuerle
Dec 30, 1992·Biochemical and Biophysical Research Communications·Y J SuzukiL Packer
Sep 1, 1992·The Journal of Clinical Investigation·J D Firth, P J Ratcliffe
Apr 1, 1992·The American Journal of Physiology·P A Marsden, B M Brenner
Feb 28, 1990·Biochemical and Biophysical Research Communications·Y MatsumuraS Morimoto
Feb 28, 1990·Biochemical and Biophysical Research Communications·T D HexumM R Brown
Jan 1, 1990·Life Sciences·Y ShiboutaK Nishikawa
Jan 1, 1989·Free Radical Research Communications·C J GreenB J Fuller
Oct 1, 1984·The Journal of Clinical Investigation·M S PallerT F Ferris
Aug 1, 1995·Free Radical Biology & Medicine·L PackerH J Tritschler
Feb 1, 1994·Journal of the American Society of Nephrology : JASN·R A ZagerB Torok-Storb
May 1, 1994·The British Journal of Surgery·P A Grace
May 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C K Sen, L Packer
Feb 23, 1999·Kidney International·S M WilhelmJ A Schulak
Dec 28, 1999·European Journal of Pharmacology·M TakaokaY Matsumura

❮ Previous
Next ❯

Citations

Aug 19, 2003·European Journal of Pharmacology·Toshihide FujiiYasuo Matsumura
Oct 19, 2007·Clinical and Experimental Pharmacology & Physiology·Ozer SehirliGöksel Sener
Jan 30, 2007·Pharmacology·Ender DulunduGoksel Sener
Sep 6, 2005·Biological & Pharmaceutical Bulletin·Mamoru OhkitaYasuo Matsumura
Sep 11, 2007·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Mamoru OhkitaYasuo Matsumura
Mar 12, 2013·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Masayuki KimuraMakoto Shibutani
Apr 20, 2010·Toxicon : Official Journal of the International Society on Toxinology·Valter de Sousa AlegrePaulo Flavio Silveira
Jul 12, 2008·European Journal of Pharmacology·Magdalena DudekLidia Włodek
Jul 10, 2007·European Journal of Pharmacology·Ganapathy AmudhaPalaninathan Varalakshmi
Oct 21, 2005·Basic & Clinical Pharmacology & Toxicology·Ilhami CelikH Handan Akbulut
Oct 29, 2013·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·Z CavdarG A Guner
Oct 9, 2014·Renal Failure·Halil AsciIlter Ilhan
Nov 23, 2010·Toxicon : Official Journal of the International Society on Toxinology·Juliana Marton BaronePaulo Flávio Silveira
Jan 10, 2013·Toxicology and Industrial Health·Alaa El-Din E El-SisiEthar A Moussa
Jan 10, 2017·Toxicology Letters·T J PiantaZ H Endre
Dec 18, 2004·Toxicologic Pathology·Ricardo N Pires das NevesMaria Lourdes de Pereira
Jul 6, 2018·Transplant International : Official Journal of the European Society for Organ Transplantation·Paola CasciatoEduardo Chuluyan
Jun 1, 2007·Electrolyte & Blood Pressure : E & BP·Eun Hui BaeSoo Wan Kim
Jan 15, 2014·Journal of Complementary & Integrative Medicine·Kamal Adel AminEman M Taha
Nov 23, 2007·American Journal of Physiology. Renal Physiology·Eun Hui BaeSoo Wan Kim
May 20, 2016·Journal of Cardiovascular Pharmacology·Alan S LaderReinier Beeuwkes
Feb 19, 2019·Oxidative Medicine and Cellular Longevity·Vassilios LiakopoulosEvangelia Dounousi
Aug 19, 2006·The Journal of Pharmacology and Experimental Therapeutics·Hayato KurataYasuo Matsumura
Nov 7, 2019·Biological & Pharmaceutical Bulletin·Mamoru OhkitaYasuo Matsumura
Mar 12, 2021·Biochemistry. Biokhimii︠a︡·N V AndrianovaE Y Plotnikov
Jan 7, 2005·Journal of Medicinal Chemistry·Alessandra AntonelloCarlo Melchiorre

❮ Previous
Next ❯

Related Concepts

Related Feeds