Protective effect of an arabinogalactan from black soybean against carbon tetrachloride-induced acute liver injury in mice

International Journal of Biological Macromolecules
Jian SunChanghai Jin

Abstract

In vivo hepatoprotective effect of a novel arabinogalactan (AG) from black soybean on carbon tetrachloride (CCl4)-induced acute liver injury was evaluated for the first time. Our results showed that administration of AG could significantly attenuate the increase in the levels of alkaline phosphatase, alanine transaminase and aspartate transaminase in the serum caused by CCl4 treatment. AG treatment not only significantly elevated the levels of antioxidant enzymes including superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase; but also increased the levels of non-enzyme antioxidants (glutathione and total antioxidant capacity in liver tissues) when compared with CCl4-induced acute liver injury model. In addition, AG significantly reduced lipid peroxidation levels in liver tissues. The hepatoprotective effect of high-dose of AG was comparable to that of silymarin, which served as a positive standard. This study indicated that AG had a protective effect on CCl4-induced acute liver injury.

Citations

Oct 31, 2020·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Yawei DouLong Zhao
Jul 15, 2021·Critical Reviews in Food Science and Nutrition·He LiuDanshi Zhu
May 12, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hu HuaGuixia Ding

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