Abstract
This study investigates the protective effect of aquacultured flounder fish-derived peptide (AFFP) against 2,2-azobis-(2-amidinopropane) hydrochloride (AAPH)-induced oxidative damage in a zebrafish model. Zebrafish embryos were evaluated for the protective effect by heartbeat rate, survival rate, ROS generation, lipid peroxidation, and cell death. In the results, the AAPH group showed a low survival rate, whereas the AFFP and AAPH co-treated group increased a survival rate. Also, AFFP dose-dependently reduced AAPH-induced intracellular ROS and lipid peroxidation, and decreased cell death in AAPH-induced zebrafish. These results revealed that AFFP could be used as a natural antioxidant, and that the zebrafish provides an alternative in vivo model to efficiently evaluate the antioxidative effects of peptides on fishes.
References
Sep 30, 1991·The American Journal of Medicine·A BastC J Doelman
Jul 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C B KimmelT F Schilling
Dec 13, 1996·Cell·J S Eisen
Dec 16, 1998·The British Journal of Nutrition·A T DiplockJ Viña-Ribes
Sep 15, 1999·Proceedings of the National Academy of Sciences of the United States of America·M C Fishman
Dec 22, 1999·Immunopharmacology·H Fujita, M Yoshikawa
Aug 2, 2003·Nature Biotechnology·Franz B PichlerDonald R Love
Feb 3, 2005·Journal of Agricultural and Food Chemistry·Blanca Hernández-LedesmaLourdes Amigo
Aug 25, 2005·BioTechniques·Stephane BerghmansJohn P Kanki
Nov 25, 2005·Bioscience Reports·Jeroen den Hertog
Jan 13, 2006·Trends in Cell Biology·Dimitris Beis, Didier Y R Stainier
Mar 21, 2007·Pigment Cell Research·Tae-Young ChoiTae-Jin Yoon
Jul 24, 2007·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Christa Mersich, Alois Jungbauer
Nov 6, 2007·Antioxidants & Redox Signaling·Jyoti D Malhotra, Randal J Kaufman
Aug 23, 2008·The International Journal of Biochemistry & Cell Biology·Tianfeng Chen, Yum-Shing Wong
May 5, 2009·Journal of Food Science·S Y WangJ J Zhou
Jan 26, 2011·Peptides·Bomi RyuSe-Kwon Kim
Jun 7, 2011·Fish & Shellfish Immunology·M Enis YonarSibel Silici
May 5, 2012·Fish & Shellfish Immunology·M Enis Yonar
Nov 14, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ju-Young KoYou-Jin Jeon
Feb 16, 2013·Food Chemistry·Min-Cheol KangYou-Jin Jeon
Citations
Jun 18, 2016·Oxidative Medicine and Cellular Longevity·Shuang HanHui Liu
Sep 16, 2015·Fish & Shellfish Immunology·Jaqueline D Biller-TakahashiElisabeth C Urbinati
Jun 20, 2017·Fish & Shellfish Immunology·Lin FengXiao-Qiu Zhou
Apr 17, 2020·Marine Drugs·Thilina U JayawardenaYou-Jin Jeon
Jul 13, 2020·Fish Physiology and Biochemistry·Long YinJun Jiang
Dec 7, 2019·Food Science and Biotechnology·Jung Yoon YangDae-Seop Shin
May 13, 2015·Carbohydrate Polymers·Min-Cheol KangYou-Jin Jeon
Aug 2, 2020·Chemosphere·Lei ZhaoYan-Fen Ma