PMID: 24363722Apr 1, 2010Paper

Protective Effect of Aqueous Extract of Terminalia arjuna against Dehydrating Induced Oxidative Stress and Uremia in Male Rat

Iranian Journal of Pharmaceutical Research : IJPR
Koushik DasDilip Kumar Nandi

Abstract

The present study has been designed to find out the protective effect of aqueus extract of Terminalia arjuna against dehydration induced oxidative stress and uremia, protection by plant extract in male Wister strain albino rats, and therefore to find out the scientific basis of local use of Terminalia arjuna bark extract by village ayurved doctors to protect the progressive kidney disorder (renal failure) relating to dehydration and other related problems. Water withdrawing for 15 days in male Wister strain albino rats resulted in a significant elevation in the level of blood nitrogenous products (i.e. urea and creatinine). On the other hand, it increased the levels of free radicals, melondialdehyde (MDA) and conjugated dienes (CD) along with a significant diminution in the activities of superoxide dismutse (SOD) and catalase in blood. All these water markers were significantly prevented after administration of aqueous extract of Terminalia arjuna bark. These results suggest that dehydration induced oxidative stress and uremia in male rats may be protected by using the above mentioned medicinal plants extract. This herbal extract showed no toxic effect on blood and kidney, based on the measurements of glutamic oxaloacetic trans...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia
Koushik DasDilip K Nandi
Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society
Shrabani PradhanDilip K Nandi
Redox Report : Communications in Free Radical Research
Nadana Saravanan, Namasivayam Nalini
© 2021 Meta ULC. All rights reserved