Protective effect of Arque-Ajeeb on acute experimental diarrhoea in rats

BMC Complementary and Alternative Medicine
Mohd Aleem KhanShadab Zafar

Abstract

Diarrhoea is a major health problem for children worldwide, accounting for 5-8 million deaths each year. Arque-Ajeeb (AA) is a compound formulation of Unani medicine. It is reputed for its beneficial effects in the treatment of diarrhoea and cholera, but the claim of its efficacy is yet to be tested. Therefore the present study has been planned to investigate the real efficacy of this drug in rats. The effect of Arque-Ajeeb was investigated for antidiarrhoeal activity against charcoal-induced gut transit, serotonin-induced diarrhoea and PGE2-induced small intestine enteropooling in rats. The control, standard and test groups of experimental animals were administered with normal saline (p.o.), diphenoxylate hydrochloride (5 mg/kg, p.o.) and Arque-Ajeeb (0.07 ml and 0.14 ml/kg, p.o.) respectively except the control group of PGE2-induced small intestine enteropooling which received only 5% ethanol in normal saline (i.p.). Charcoal (10 ml/kg, p.o.) and serotonin (600 micrograms/kg, i.p.) were administered after 30 min, while PGE2 (100 micrograms/kg, p.o.) was administered immediately afterwards. The distance traveled by charcoal in small intestine was measured after 15 and 30 min of charcoal administration, diarrhoea was observed e...Continue Reading

References

Sep 20, 1979·World Journal of Surgery·B M Jaffe
Jul 1, 1968·British Journal of Pharmacology and Chemotherapy·A B Drakontides, M D Gershon
Sep 9, 1982·The New England Journal of Medicine·G Levy
Aug 10, 2000·British Journal of Clinical Pharmacology·C J LoweJ Hudson
Feb 28, 2002·Fitoterapia·Swati BiswasB P Saha
Feb 1, 1963·British Journal of Pharmacology and Chemotherapy·M DAY, J R VANE

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Citations

Oct 22, 2008·Journal of Herbal Pharmacotherapy·Y S BiradarK R Khandelwal
Oct 19, 2010·Evidence-based Complementary and Alternative Medicine : ECAM·T B LimaE Leonardecz
Sep 24, 2020·Drug Metabolism and Personalized Therapy·Md Anzar AlamMariyam Ahad

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