Protective effect of astaxanthin against multiple organ injury in a rat model of sepsis

The Journal of Surgical Research
Liping ZhouAimin Wang

Abstract

Astaxanthin, a xanthophyll carotenoid, holds exceptional promise as an antioxidant, anti-inflammatory, and anticancer agent. No evidence has been published whether it has protective effects on sepsis. The study aimed to investigate the potential effects of astaxanthin on sepsis and multiple organ dysfunctions. Sepsis was induced by cecal ligation and puncture (CLP) in Sprague-Dawley rats. Animals subjected to CLP and sham-operated control rats were given vehicle or astaxanthin 100 mg/kg/d by oral gavage for 7 d before the operation. The rats were killed at the indicated time points, and the specimen was collected. Cytokines and multiorgan injury-associated enzymatic and oxidative stress indicators were investigated. Multiorgan tissues were assessed histologically, the peritoneal bacterial load and the 72-h survival was observed too. Sepsis resulted in a significant increase in serum tumor necrosis factor-α, interleukin-1β, and interleukin-6 levels showing systemic inflammatory response; it also caused a remarkable decrease in the superoxide dismutase activity and a significant increase in the malondialdehyde content showing oxidative damage; sepsis caused a great increase in organ injury-associated indicators, including blood u...Continue Reading

References

May 22, 2001·Archives of Biochemistry and Biophysics·A MortensenT G Truscott
Apr 23, 2003·Intensive & Critical Care Nursing : the Official Journal of the British Association of Critical Care Nurses·Shelley Dolan
May 3, 2003·Trends in Biotechnology·Martin GuerinMiguel Olaizola
Nov 24, 2004·The Journal of Surgical Research·G M KoksalH Uzun
Jun 15, 2005·International Immunopharmacology·Göksel SenerGözde Erkanli
Dec 15, 2005·Biochimica Et Biophysica Acta·Shey-Shing SheuM W Anders
Jan 25, 2006·Critical Reviews in Food Science and Nutrition·I Higuera-CiaparaF M Goycoolea
Jul 11, 2006·Journal of Pharmacological Sciences·Naoyuki Matsuda, Yuichi Hattori
Jul 13, 2006·FEMS Immunology and Medical Microbiology·Shuhei Sakaguchi, Shinobu Furusawa
Jun 22, 2007·Critical Care Medicine·Henry E WangDonald M Yealy
Sep 4, 2008·Critical Care Medicine·Alan E JonesUNKNOWN Emergency Medicine Shock Research Network investigators
Oct 23, 2009·Journal of Cardiovascular Pharmacology and Therapeutics·Paula R AugustiTatiana Emanuelli
Jan 7, 2011·Veterinary Immunology and Immunopathology·Boon P ChewJean Soon Park
Mar 19, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Marumi OhnoMayumi Ishizuka
May 21, 2011·British Journal of Anaesthesia·H F Galley
Feb 22, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Robert G Fassett, Jeff S Coombes
Jan 10, 2014·Marine Drugs·Ranga Rao AmbatiRavishankar Gokare Aswathanarayana
May 14, 2014·European Journal of Nutrition·Assaâd SilaZouheir Sahnoun

❮ Previous
Next ❯

Citations

Dec 9, 2015·International Immunopharmacology·Hongyu ZhaoMin Zhao
Mar 30, 2016·The Journal of Surgical Research·Qian-Yi PengYu-Hang Ai
Dec 20, 2017·Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery·Maxley Martins AlvesPaulo Roberto de Melo-Reis
Aug 10, 2017·Brazilian Journal of Biology = Revista Brasleira De Biologia·L A AraújoN J Silva-Júnior
Sep 17, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jianbin BiJingyao Zhang
Apr 15, 2021·American Journal of Perinatology·Hasan AkdumanMurat Çağlayan
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Barbara Stachowiak, Piotr Szulc
Feb 25, 2021·Shock·Mariane C G Leite-AvalcaChristian Lehmann
Apr 11, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhiling LiMingshi Yang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.