Abstract
Accelerated atherosclerosis in patients suffering from diabetes represents a major cause of morbidity and mortality. The aim of present study was to investigate the protective effects conferred by atorvastatin (AVT) meditated by the HMGCR gene in diabetic rats with atherosclerosis. Serum triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very-low-density lipoprotein cholesterol (VLDL-C), fasting blood glucose (FBG) and serum insulin (INS) were all determined by means of in vivo experiments. Following the establishment of the diabetic model of atherosclerosis, the expressions of HMGCR, low density lipoprotein receptor (LDLR), fatty acid synthase (FASN) were detected by reverse transcription quantitative polymerase chain reaction (RT-qPCR) and Western blot analysis in the vitro experiments. Flow cytometry was adopted in order to detect cell cycle and apoptosis. The in vivo experiments results indicated that FBG and INS among the diabetic arteriosclerosis rats exhibited markedly higher levels; after injected with AVT and HMGCR, decreased contents of TC, TG, LDL-C and VLDL-C, while increased contents of HDL-C as well as an increased positive rate of ...Continue Reading
References
Sep 1, 1980·Diabetes Care·S Howe-DaviesR C Turner
Sep 23, 2000·Nature·A J Lusis
Jan 22, 2002·Current Opinion in Lipidology·G Steiner
Oct 5, 2002·Journal of Lipid Research·Joseph L DixonMichael Sturek
Dec 18, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Thomas A Clarke, Lucy A Waskell
Apr 2, 2003·The American Journal of Cardiology·Joseph A VitaJohn F Keaney
Jul 22, 2005·The New England Journal of Medicine·Christoph WannerUNKNOWN German Diabetes and Dialysis Study Investigators
Oct 6, 2005·Clinical Chemistry and Laboratory Medicine : CCLM·Despoina M Choumerianou, George V Z Dedoussis
Jun 12, 2009·Pediatric Diabetes·Robert Dalla PozzaSusanne Bechtold
Nov 20, 2009·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Renata N FreitasSheila Rodwell
Mar 23, 2010·Acta Pharmacologica Sinica·Xiao-mei BaoGuo-ping Lu
Mar 24, 2011·Journal of Clinical Pharmacology·Jae Yong ChungMin Soo Park
Jul 13, 2011·Acta Diabetologica·Nikolaos P E KadoglouChristos D Liapis
Dec 20, 2011·Computers in Biology and Medicine·M V K KarthikPratyoosh Shukla
Feb 1, 2010·Animal : an International Journal of Animal Bioscience·A CánovasR N Pena
May 3, 2012·Annals of the New York Academy of Sciences·Lina Badimon, Gemma Vilahur
Mar 9, 2013·Breast Cancer Research and Treatment·Olöf BjarnadottirSigne Borgquist
Oct 2, 2013·Journal of Advanced Pharmaceutical Technology & Research·Meenakshi Lella, K Indira
Jan 10, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Hae Chang JeongYoungkeun Ahn
Jan 22, 2014·European Journal of Pharmacology·Jinzi SuYangming Cao
Apr 15, 2015·The Journal of Cell Biology·Ira TabasGary K Owens
May 26, 2015·Cytokine & Growth Factor Reviews·Dipak P Ramji, Thomas S Davies
Sep 27, 2015·Basic & Clinical Pharmacology & Toxicology·Alejandro CuevasLuis A Salazar
Oct 16, 2015·Pharmacogenetics and Genomics·Valerie LeducRobert Dufour
Jun 14, 2016·Journal of Photochemistry and Photobiology. B, Biology·Sandra M AyukNicolette N Houreld
Oct 6, 2016·Oncotarget·Shiv Ram KrishnSurinder K Batra
Nov 30, 2016·European Journal of Pharmacology·Jung Joo YoonHo Sub Lee
Citations
Aug 26, 2019·Molecular and Cellular Biochemistry·Xiaoqian LouLiqun Ren
Aug 28, 2020·Frontiers in Physiology·Dongxing LiuBo Hu
Nov 28, 2020·Food & Function·Xiong LiJinhua Piao
Apr 28, 2021·European Journal of Pharmacology·Shengze XiaoHongmei Liu
Jul 27, 2021·Frontiers in Genetics·Farzad GhafouriSamantha Larose