Protective effect of beraprost sodium, a new chemically stable prostacyclin analogue, against the deterioration of baroreceptor reflex following transient global cerebral ischaemia in dogs

British Journal of Pharmacology
J KuriharaH Kato

Abstract

1. A possible cerebroprotective effect of a chemically stable prostacyclin analogue, beraprost sodium, was investigated in a canine model of cerebral ischaemia. Cerebral ischaemia was produced by the combined occlusions of the left subclavian and the brachiocephalic arteries with preceding ligations of the intercostal arteries. 2. The decrease in baroreceptor reflex sensitivity (BRS), measured by phenylephrine-induced reflex bradycardia, following 5 min ischaemia was used to assess the cerebroprotective effect. 3. Beraprost (1 microgram kg-1 min-1 i.v., infused for 15 min just before ischaemia) completely prevented the decrease in BRS. Although the lower dose of beraprost (0.1 microgram kg-1 min-1 i.v.) failed to show such a protective effect, its inhibitory effect on ADP-induced platelet aggregation was as potent as that of the higher dose. 4. The extent of decrease in BRS was inversely correlated with the extent of the residual blood flow in the medulla oblongata during ischaemia. Since beraprost did not affect the extent of the residual blood flow during ischaemia, its cerebroprotective effect could not be ascribed to the reduction of the degree of ischaemia by increasing collateral blood flow to the brain. 5. Post-ischaemic...Continue Reading

References

Nov 1, 1979·Stroke; a Journal of Cerebral Circulation·J M Hallenbeck, T W Furlow
Mar 1, 1979·Stroke; a Journal of Cerebral Circulation·C K Petito
Jun 1, 1979·European Journal of Pharmacology·M L OgletreeK C Nicolaou
Nov 1, 1979·Neurology·J H DoughertyB B Weksler
Aug 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M HambergB Samuelsson
Sep 1, 1988·Journal of Cardiovascular Pharmacology·H BittermanA M Lefer
Feb 1, 1989·Japanese Journal of Pharmacology·J KuriharaH Kato
Jun 8, 1989·European Journal of Pharmacology·J KuriharaH Kato
Jul 26, 1988·European Journal of Pharmacology·T TerawakiY Masuda
Dec 1, 1986·British Journal of Pharmacology·T AkibaN Toda
Jul 1, 1985·Stroke; a Journal of Cerebral Circulation·A B ShahB M Coull
Oct 1, 1988·Stroke; a Journal of Cerebral Circulation·R JosephG D'Andrea
Apr 1, 1988·Stroke; a Journal of Cerebral Circulation·P TurcániB Mihara
Nov 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·Y MasudaM Shimizu
Jan 1, 1987·Japanese Journal of Pharmacology·T UmetsuS Nishio
Jan 1, 1985·Progress in Brain Research·F A Welsh
Mar 1, 1985·Stroke; a Journal of Cerebral Circulation·T P Obrenovitch, J M Hallenbeck
Dec 1, 1973·Archives of Neurology·E G Fischer
Sep 17, 1982·Biochimica Et Biophysica Acta·G J BlackwellS Moncada
Sep 1, 1983·Stroke; a Journal of Cerebral Circulation·W van den KerckhoffV Hossmann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bradyarrhythmias

Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.

Related Papers

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Cornelia LundbladPeter Bentzer
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
K Bian, N Toda
© 2021 Meta ULC. All rights reserved