Protective effect of berberine on aconite‑induced myocardial injury and the associated mechanisms

Molecular Medicine Reports
Xue-Yan ChenSu-Wen Su

Abstract

Aconitum plants, which have analgesic, diuretic and anti‑inflammatory effects, have been widely used to treat various types of disease. However, the apparent toxicity of Aconitum‑derived agents, particularly in the cardiovascular system, has largely limited their clinical use. Thus, the present study investigated whether berberine (Ber), an isoquinoline alkaloid, may reduce myocardial injury induced by aconitine (AC) in rats and the underlying mechanisms. Rats (n=40) were randomly divided into four groups: Control, Chuan‑wu and Chuan‑wu + Ber (8 and 16 mg/kg doses). Electrocardiograms (ECG) of the rats were recorded and serum biomarkers of cardiac function [lactate dehydrogenase (LDH), creatine kinase (CK) and CK‑MB] were assayed. Histopathological changes were assessed using myocardial tissue sectioning and hematoxylin and eosin staining. Additionally, the effects of Ber on AC‑induced arrhythmias in rats were observed. The changes in ECG following AC perfusion were observed, and the types and onset time of arrhythmias were analyzed. Furthermore, the effects of Ber and AC on papillary muscle action potentials were observed. The results suggested that Ber ameliorated myocardial injury induced by Chuan‑wu, which was indicated by ...Continue Reading

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