Abstract
The purpose of the experiment was to study the effects of betulinic acid (BA) on adjuvant-induced arthritis in rats. The rat model of rheumatoid arthritis (AA) was established by Freund's complete adjuvant. Arthritis index, joint pathology, toe swelling, hemorheology, related cytokines and ROCK/NF-κB signaling pathway were measured in rats. BA can significantly inhibit the arthritis index, improve joint pathology, reduce toe swelling, improve blood rheology, improve synovial cell apoptosis, and restore related cytokine negative regulation of ROCK/NF-κB signaling pathways. BA has an obvious therapeutic effect on joint inflammation of toes in AA model rats, which may be due to the regulation of ROCK/NF-κB signaling pathway.
References
Oct 1, 1995·Nature Medicine·E PishaD M Brown
Jul 8, 1999·Journal of Medicinal Chemistry·R C Newton, C P Decicco
Jun 29, 2000·Annual Review of Biochemistry·K KaibuchiM Amano
May 31, 2003·Nature Reviews. Drug Discovery·Josef S Smolen, Günter Steiner
Dec 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yasuo NikiNorihiro Tada
Oct 12, 2004·Toxicology Letters·M G P CoelhoK C C Sabino
Nov 5, 2008·The Journal of Clinical Investigation·Marc Feldmann
Oct 7, 2009·International Immunopharmacology·Jalal A JazayeriAnn B Vernallis
Apr 15, 2014·ISRN Rheumatology·Mradu GuptaArup Mukherjee
Sep 27, 2014·Inflammation·Lingpeng ZhuTianhua Yan
Jan 24, 2015·International Immunopharmacology·Tong ChenHui Ji
Aug 1, 2015·International Immunopharmacology·Zhongyan ZhaoChunhua Ma
Sep 13, 2015·Chemico-biological Interactions·Wenjiao JiangXuansheng Ding
Oct 11, 2015·Inflammation·Tong ChenZhanqiang Ma
Oct 31, 2015·Free Radical Research·Tong ChenTianhua Yan
Dec 23, 2015·Neuropharmacology·Lingpeng ZhuChunhua Ma
Apr 16, 2016·IUBMB Life·Zhou LanXiuqiao Zhang
Jun 11, 2016·International Immunopharmacology·Zhiheng HuangWeiwei Tao
Oct 26, 2016·Molecular Medicine Reports·Xia ZhangYan Chen
Oct 30, 2016·Oncotarget·Deng XueyangHao Kun
Nov 16, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ritesh RajuGerald Münch
Citations
Nov 14, 2019·BioFactors·Yuntai HuangYogendra Singh
Jun 8, 2021·Frontiers in Pharmacology·Liang Liang BaiJun Yu
Oct 8, 2021·Drug Delivery·Xin-Yi LiuXiu Wang