Protective effect of betulinic acid on Freund's complete adjuvant-induced arthritis in rats

Journal of Biochemical and Molecular Toxicology
Ding HuiminWei Juncheng

Abstract

The purpose of the experiment was to study the effects of betulinic acid (BA) on adjuvant-induced arthritis in rats. The rat model of rheumatoid arthritis (AA) was established by Freund's complete adjuvant. Arthritis index, joint pathology, toe swelling, hemorheology, related cytokines and ROCK/NF-κB signaling pathway were measured in rats. BA can significantly inhibit the arthritis index, improve joint pathology, reduce toe swelling, improve blood rheology, improve synovial cell apoptosis, and restore related cytokine negative regulation of ROCK/NF-κB signaling pathways. BA has an obvious therapeutic effect on joint inflammation of toes in AA model rats, which may be due to the regulation of ROCK/NF-κB signaling pathway.

References

Jul 8, 1999·Journal of Medicinal Chemistry·R C Newton, C P Decicco
Jun 29, 2000·Annual Review of Biochemistry·K KaibuchiM Amano
May 31, 2003·Nature Reviews. Drug Discovery·Josef S Smolen, Günter Steiner
Dec 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yasuo NikiNorihiro Tada
Nov 5, 2008·The Journal of Clinical Investigation·Marc Feldmann
Oct 7, 2009·International Immunopharmacology·Jalal A JazayeriAnn B Vernallis
Jan 24, 2015·International Immunopharmacology·Tong ChenHui Ji
Jun 11, 2016·International Immunopharmacology·Zhiheng HuangWeiwei Tao
Oct 26, 2016·Molecular Medicine Reports·Xia ZhangYan Chen
Nov 16, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ritesh RajuGerald Münch

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