Protective effect of Bojungikki-tang, a traditional herbal formula, against alcohol-induced gastric injury in rats

Journal of Ethnopharmacology
Mee-Young LeeHyeun-Kyoo Shin

Abstract

Oxidative stress plays an important role in the pathogenesis of ethanol-induced acute gastric mucosal injury. Bojungikki-tang (Hochuekkito in Japanese, Bu-zhong-yi-qi-tang in Chinese) is a traditional herbal formula used in Korea, Japan, and China to treat allergic diseases and gastrointestinal disorders. However, the mechanism responsible for its actions has not been investigated experimentally. The aims of this study were to investigate whether Bojungikki-tang water extract (BJITE) has protective effects against ethanol-induced acute gastric injury in rats and to perform an acute toxicity study to evaluate its safety. In this rat model, gastric mucosal injury was imposed by oral administration of 5 mL/kg body weight of absolute ethanol. BJITE at one of two doses (200 or 400 mg/kg body weight) was administered by gavage 2 h before ethanol administration. Gastric tissues were collected and analyzed to assess the gastric injury index, and content or activity of catalase, superoxide dismutase (SOD), malondialdehyde (MDA), glutathione (GSH), glutathione-S-transferase (GST), glutathione reductase (GR), and glutathione peroxidase (GPx). Acute administration of ethanol significantly increased the gastric injury index concomitantly wi...Continue Reading

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Citations

Oct 21, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Woo-Young JeonHyekyung Ha
Dec 17, 2014·BMC Complementary and Alternative Medicine·Mingzi OuyangXiaoshan Zhao
Nov 3, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Woo-Young JeonHyeun-Kyoo Shin
May 9, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·A L RozzaC H Pellizzon
Jan 24, 2017·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Min HeJian Jiang
Feb 2, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Sae-Rom YooChang-Seob Seo
Aug 16, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Bumjung KimKyungjin Lee
Apr 20, 2020·Basic & Clinical Pharmacology & Toxicology·Amany Abdel-Mageed AlzokakyNahed A Raslan

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