Protective effect of botulinum toxin A after cutaneous ischemia-reperfusion injury

Scientific Reports
Akihiko UchiyamaSei-Ichiro Motegi

Abstract

Botulinum toxin A (BTX-A) blocks the release of acetylcholine vesicles into the synaptic space, and has been clinically used for aesthetic indications, neuromuscular disorders and hyperhidrosis. Several studies have demonstrated that BTX-A enhanced the blood flow and improved ischemia in animal models. Our objective was to assess the effects of BTX-A on cutaneous ischemia-reperfusion (I/R) injuries, mimicking decubitus ulcers. The administration of BTX-A in I/R areas significantly inhibited the formation of decubitus-like ulcer in cutaneous I/R injury mouse model. The number of CD31(+) vessels and αSMA(+) pericytes or myofibroblasts in wounds were significantly increased in the I/R mice treated with BTX-A. The hypoxic area and the number of oxidative stress-associated DNA-damaged cells and apoptotic cells in the I/R sites were reduced by BTX-A administration. In an in vitro assay, BTX-A significantly prevented the oxidant-induced intracellular accumulation of reactive oxygen species (ROS) in vascular endothelial cells. Furthermore, the administration of BTX-A completely suppressed the ulcer formation in an intermittent short-time cutaneous I/R injury model. These results suggest that BTX-A might have protective effects against ...Continue Reading

References

Sep 23, 1994·Cell·C Nathan, Q W Xie
Apr 12, 2000·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·S M PeirceG T Rodeheaver
Sep 26, 2000·Head & Neck·W R Carroll, R M Esclamado
Apr 30, 2002·Seminars in Immunology·Francis W LuscinskasSunil K Shaw
Sep 27, 2002·The New England Journal of Medicine·Fredrick M Wigley
Sep 30, 2003·Journal of the American Society of Nephrology : JASN·Kengo FuruichiHitoshi Yokoyama
Jan 21, 2004·The Journal of Surgical Research·Russell R ReidThomas A Mustoe
Apr 17, 2004·European Journal of Clinical Investigation·T SychaP Schnider
Sep 17, 2004·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Istvan StadlerRaymond J Lanzafame
Feb 28, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Takanori HayasakiMotohiro Takeya
Jan 27, 2007·Plastic and Reconstructive Surgery·Allen L Van BeekMarc R Pritzker
Jan 26, 2008·The Journal of Investigative Dermatology·Yuki SaitoKazuhiko Takehara
Apr 26, 2008·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Taek Kyun KimHo Yun Chung
Mar 5, 2009·The Journal of Hand Surgery·Alero FregeneAamir Siddiqui
Jul 2, 2009·Plastic and Reconstructive Surgery·Michael W NeumeisterCarisa M Cooney
Aug 8, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Young Seok KimKwan-Chul Tark
Jul 17, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J OlverUNKNOWN Cerebral Palsy Institute
Aug 3, 2010·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Mehdi FathiMohammad H Kardar
Dec 8, 2010·The Journal of Hand Surgery·Michael W Neumeister
Jul 9, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Sei-ichiro MotegiMark C Udey
Sep 29, 2011·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Ismail KüçükerSühan Ayhan
Jan 25, 2012·Der Urologe. Ausg. A·H Schulte-Baukloh
Apr 18, 2012·Archives of Dermatology·Lauren SmithAndrew G Franks
Jul 12, 2012·Nature Reviews. Rheumatology·Ariane L Herrick
May 9, 2013·The Journal of Surgical Research·Dennis F SchweizerJan A Plock
Jul 3, 2013·Annals of Plastic Surgery·Tae Hwan ParkJune-Kyu Kim
May 20, 2014·The American Journal of Pathology·Akihiko UchiyamaSei-ichiro Motegi

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Citations

May 2, 2020·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Yuta InoueSei-Ichiro Motegi
Jan 31, 2019·The International Journal of Lower Extremity Wounds·Jiaojiao ZhongJun-Min Zhang
Jan 24, 2021·Communications Biology·Tomohiko MatsuoKo Kobayakawa
May 27, 2021·Plastic and Reconstructive Surgery. Global Open·Jenna R StoehrGregory A Dumanian
Jun 11, 2021·Acta Pharmacologica Sinica·Delphine JiHong-Shuo Sun
Jul 21, 2021·Expert Review of Neurotherapeutics·Muhammad Ubaid HafeezJoseph Jankovic
Aug 3, 2021·Journal of Plastic Surgery and Hand Surgery·Shupeng ShiJianda Zhou
Aug 31, 2021·Toxicology Reports·Farnoosh FooladvandMohammad Abdollahi

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