Protective effect of bovine milk against HCl and ethanol-induced gastric ulcer in mice

Journal of Dairy Science
Jeong-Hyun YooHae-Jeung Lee

Abstract

The purpose of this study was to investigate the gastroprotective effects of bovine milk on an acidified ethanol (HCl-ethanol) mixture that induced gastric ulcers in a mouse model. Mice received different doses of commercial fresh bovine milk (5, 10, and 20 mL/kg of body weight) by oral gavage once a day for 14 d. One hour after the last oral administration of bovine milk, the HCl-ethanol mixture was orally intubated to provoke severe gastric damage. Our results showed that pretreatment with bovine milk significantly suppressed the formation of gastric mucosa lesions. Pretreatment lowered gastric myeloperoxidase and increased gastric mucus contents and antioxidant enzymes catalase and superoxide dismutase. Administration of bovine milk increased nitrate/nitrite levels and decreased the malondialdehyde levels and the expression of proinflammatory genes, including transcription factor nuclear factor-κB, cyclooxygenase-2, and inducible nitric oxide synthase in the stomach of mice. These results suggest that bovine milk can prevent the development of gastric ulcer caused by acid and alcohol in mice.

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Mar 15, 1979·Clinica Chimica Acta; International Journal of Clinical Chemistry·M Minami, H Yoshikawa
Mar 1, 1982·The Journal of Investigative Dermatology·P P BradleyG Rothstein
Jan 1, 1980·Ergebnisse der inneren Medizin und Kinderheilkunde·J C Bode
Oct 1, 1982·Analytical Biochemistry·L C GreenS R Tannenbaum
Dec 27, 1996·The Journal of Biological Chemistry·W L SmithD L DeWitt
Aug 10, 2000·Gastroenterology·J L Wallace, M J Miller
May 2, 2003·Bioscience, Biotechnology, and Biochemistry·Yoshihiko UshidaHirotoshi Hayasawa
Aug 15, 2003·World Journal of Gastroenterology : WJG·Jin-Sheng GuoMarcel Wing Leung Koo
Nov 17, 2004·Free Radical Biology & Medicine·Stephen S LeonardXianglin Shi
Apr 15, 2006·Inflammation & Allergy Drug Targets·John L Wallace
Jan 20, 2007·Journal of Dairy Science·Y UshidaM Takase
Sep 15, 2007·World Journal of Gastroenterology : WJG·Duygu Dee Harrison-Findik
Oct 19, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shannon Reagan-ShawNihal Ahmad
Oct 16, 2008·World Journal of Gastroenterology : WJG·Jin-Shui PanJian-Lin Ren
Oct 14, 2009·World Journal of Gastroenterology : WJG·Sae-Kwang KuSeong-Soo Roh
Oct 27, 2009·Chemico-biological Interactions·Talita C MoraisFlávia A Santos
May 12, 2010·Cold Spring Harbor Perspectives in Biology·Toby Lawrence
Aug 20, 2010·BMC Complementary and Alternative Medicine·Atsushi OyagiHideaki Hara
May 15, 2012·Journal of Physiology and Biochemistry·Masoud AlirezaeiArash Kheradmand
Jan 5, 2014·Mediators of Inflammation·Hideto KawarataniHiroshi Fukui
Oct 4, 2014·World Journal of Gastroenterology : WJG·Yun ShaoWei-Hao Sun
Nov 6, 2014·Gastroenterology Research and Practice·Zhen WangJin-Lu Liu
Mar 3, 2015·Journal of Photochemistry and Photobiology. B, Biology·Hanan A Fahmy, Amel F M Ismail
Sep 26, 2015·Digestive Diseases and Sciences·Nathalia S CarvalhoJand Venes R Medeiros
Sep 1, 2016·Saudi Journal of Biological Sciences·D P MohantyP S Sahu
Oct 27, 2016·Chemico-biological Interactions·Ana Roseli S RibeiroSara Maria Thomazzi
Mar 30, 2017·Toxins·Olga Sokolova, Michael Naumann

❮ Previous
Next ❯

Citations

May 28, 2020·Immunological Investigations·Svjetlana MaticVermont P Dia
Mar 19, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Jun ZhangBi-Wei Song
Nov 3, 2020·Molecular Biology Reports·Yasin DuranAhsen Yılmaz
Feb 13, 2021·Scientific Reports·Enrico GugliandoloRosalia Crupi
May 18, 2021·Dose-response : a Publication of International Hormesis Society·Mohamed F RadwanNabil A Alhakamy
Aug 10, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Luisa Ferreira CruzMarcelo Gonzaga de Freitas Araújo
Sep 7, 2021·Frontiers in Nutrition·Xin ChenYanlong Wang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.