Protective effect of bovine milk whey protein concentrate on the ulcerative lesions caused by subcutaneous administration of indomethacin

Journal of Medicinal Food
C F RosaneliV C Sgarbieri

Abstract

The protective effect of a whey protein concentrate (WPC) was studied in three models of stomach ulcerative lesions induction: subcutaneous injection of indomethacin, and stress induced by either intraperitoneal injection of reserpine, or immobilization and holding in the cold (4 degrees C, 2 hours). Adult Wistar rats (300-400 g) were used for acute (single-dose), repetitive, or subchronic (10 days) administration of WPC prior to treatment with the ulcerogenic factors. The best protection was achieved in the indomethacin model for repetitive and subchronic experiments, reaching 50.1% and 44%, respectively, inhibition of the ulcerative lesions, which was significant at 1% probability (P <.01). For the immobilization and cold model, maximum inhibition by WPC was 22.1%, and that for the reserpine model was 23.8%. In both models the inhibition was not significant (P >.05) compared with saline (negative control).

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Citations

Apr 1, 2010·World Journal of Gastroenterology : WJG·Cecilia RodríguezGraciela Font de Valdez
Jan 12, 2008·Journal of the American College of Nutrition·Geoffrey W Krissansen
Feb 27, 2018·Journal of Dairy Science·Jeong-Hyun YooHae-Jeung Lee
Dec 25, 2008·The Journal of Nutrition·Daniel RusuPatrice E Poubelle
Dec 8, 2017·Journal of Medicinal Food·Wilman CarrilloJoão Ernesto de Carvalho

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