Protective effect of Bu-Zhong-Yi-Qi decoction, the water extract of Chinese traditional herbal medicine, on 5-fluorouracil-induced intestinal mucositis in mice

Human & Experimental Toxicology
H GouC Wang

Abstract

Intestinal mucositis is a serious toxic side effect of 5-fluorouracil (5-FU) treatment. Bu-Zhong-Yi-Qi decoction (BZYQD), a water extract of Chinese traditional herbal medicine, is widely used in chemotherapy in Asia as an alternative treatment to reduce the side effects of chemotherapy. However, the mechanism is unknown. To evaluate its mechanism, we investigated the effect of BZYQD on 5-FU-induced intestinal mucositis in mice, especially with regard to apoptosis in the intestinal mucosal epithelia. In the present study, mice were divided into three groups: control, 5-FU, and 5-FU + BZYQD. Mice in the 5-FU and 5-FU + BZYQD groups were administered 5-FU (100 mg/kg/day, intraperitoneally) for 6 days, and the mice in the latter group were given BZYQD (8 g/kg/day, intragastrically) beginning 4 days before 5-FU and continuing until the termination of the experiment. Loss in body weight and diarrhea during the 5-FU treatment were significantly attenuated by administration of BZYQD. The morphological signs of intestinal damage, including shortened villi height, crypt destruction, apoptosis, and necrosis, in intestinal mucosal epithelia were also reversed, accompanied by reduced neutrophil infiltration, nitrite levels, and inflammator...Continue Reading

References

May 15, 2002·Clinical Physiology and Functional Imaging·Nils HacksteinWigbert S Rau
Jun 18, 2002·The American Journal of Chinese Medicine·Sung-Ho KimSung-Kee Jo
Feb 21, 2007·British Journal of Pharmacology·M YamayaK Nakayama
Nov 6, 2007·Journal of Ethnopharmacology·Sien-Hung Yang, Chia-Li Yu
Jan 28, 2009·Journal of the American Geriatrics Society·Koichiro TatsumiYoshinosuke Fukuchi
Nov 10, 2010·Integrative Cancer Therapies·Jong Soo JeongSeong Woo Yoon
Dec 25, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Zhenze LiuJian Fei
Jan 1, 1996·International Journal of Urology : Official Journal of the Japanese Urological Association·T Mitsuma
Dec 1, 2011·Current Therapeutic Research, Clinical and Experimental·David TungSaurabh Saha
Apr 20, 2014·World Journal of Gastroenterology : WJG·Chun Seng LeeGlen A Doherty
Jun 20, 2014·Journal of Ethnopharmacology·Te-Hsin ChaoUNKNOWN Evidence-based Chinese Medicine Research Group
Nov 16, 2014·Journal of Cancer Research and Clinical Oncology·Huili LuAnja Moldenhauer
May 9, 2015·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Yu-Chen ChengYu-Chiang Hung

❮ Previous
Next ❯

Citations

Jun 30, 2014·Journal of Psychiatric Research·Wing-Fai YeungBacon Fung-Leung Ng
Jan 24, 2017·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Min HeJian Jiang
Jun 13, 2019·BMC Complementary and Alternative Medicine·Jing WangCheng Peng
Aug 14, 2020·Immunopharmacology and Immunotoxicology·Hasan Yousefi-ManeshAmir Rashidian
Mar 20, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Hanlin GongHongbo He
Oct 28, 2017·American Journal of Physiology. Gastrointestinal and Liver Physiology·Per T SangildMathias Rathe
Jan 10, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Yunke ZhangFeng Gao
Nov 22, 2018·Frontiers in Pharmacology·Qing-Yu ZhangLing-Dong Kong
Mar 26, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Xiuhong KangShengsheng Zhang
Aug 2, 2020·Explore : the Journal of Science and Healing·Masayuki ShimizuTadashi Ishii
Oct 14, 2021·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·J WeiY Ding
Aug 19, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Si ZhangChengliang Zhang

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
Assay

Software Mentioned

MetaMorph

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis