Protective effect of caffeine on streptozotocin-induced beta-cell damage in rats

The Journal of Pharmacy and Pharmacology
Keisuke KagamiKitaro Oka

Abstract

Many epidemiological studies have shown that coffee consumption reduces the risk of type 2 diabetes mellitus (T2D), although the reasons as to why remain unclear. In this study we investigated the effect of caffeine on pancreatic beta-cell damage in rats using the diabetogenic agent, streptozotocin (STZ). Wistar rats were given intraperitoneal injections of saline or caffeine (10, 50 or 100 mg kg(-1)). After 15 min, the rats were injected with a citrate buffer or 65 mg kg(-1) STZ. Three days after injection, an oral glucose tolerance test (OGTT) was performed on the rats. Furthermore, three days after the OGTT, the pancreas was isolated and homogenized, followed by determination of insulin content. STZ treatment significantly increased the plasma glucose level compared with the control at all times during the OGTT, which was significantly diminished by caffeine pretreatment at all doses. STZ treatment significantly decreased the plasma insulin level, however, which was not recovered by caffeine pretreatment. Pancreatic insulin content was significantly reduced by STZ treatment compared with the control, which was significantly recovered by caffeine pretreatment at a dose of 100 mg kg(-1) (P<0.01). We showed that caffeine protec...Continue Reading

References

Jan 30, 2002·Diabetes Care·Gerben B KeijzersPaul Smits
Nov 21, 2002·Cellular and Molecular Life Sciences : CMLS·P O Hassa, M O Hottiger
Jul 25, 2003·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Marc Y DonathThomas Mandrup-Poulsen
Apr 2, 2004·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Mayumi MinamisawaNobuharu Takai
Jul 7, 2005·JAMA : the Journal of the American Medical Association·Rob M van Dam, Frank B Hu
Nov 25, 2005·Diabetes·Marc Y DonathManfred Reinecke
Jan 10, 2006·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·R M van Dam
Mar 17, 2006·Pharmacology & Therapeutics·Louise A HorriganThomas J Connor
Mar 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·R EldorD Melloul
Oct 7, 2006·The American Journal of Clinical Nutrition·James A GreenbergAllan Geliebter
Nov 6, 2007·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Kitaro Oka

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Citations

Mar 12, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Xiongwen LvPengli Zhu
Dec 8, 2011·Bioscience, Biotechnology, and Biochemistry·Yuji MatsudaFumihiko Horio
Jun 21, 2014·Pharmacological Reports : PR·Pragalathan Naidoo, Md Shahidul Islam
Mar 31, 2012·Nutrition Reviews·Fausta Natella, Cristina Scaccini
Jun 13, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Vânia Ortega GutierresIguatemy Lourenço Brunetti
Jan 17, 2013·The Journal of International Medical Research·Z UrzúaE Sánchez-Pastor
Aug 2, 2017·Journal of Nutritional Science and Vitaminology·Misato KobayashiFumihiko Horio

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