Protective effect of calcitriol on podocytes in spontaneously hypertensive rat

Journal of the Chinese Medical Association : JCMA
Weiwei ShiXiangdong Yang

Abstract

Hypertension is a major global public health issue. Uncontrolled hypertension leads to organ damage, especially renal damage. Calcitriol is used to treat osteoporosis, promote bone formation, and increase bone mass. Previous studies have demonstrated that 1,25(OH)2D3, in addition to its classic role, also has multiple immune regulation and renoprotective functions and inhibits the activity of the renin-angiotensin-aldosterone system (RASS). The aim of the current study was to investigate the renoprotective effects of calcitriol in a spontaneously hypertensive rat (SHR) model. A total of 18 SHRs and 8 age-matched normal Wistar rats were enrolled. SHRs were randomly divided into a hypertensive nephropathy group (H), a hypertensive nephropathy treated with calcitriol group (D) and a control group (NS). The rats were sacrificed after 16 weeks of treatment. The blood pressure (BP) of rats were measured one time every 4 weeks. The levels of serum albumin, serum creatinine, blood calcium, serum Vitamin D and 24-h urinary protein were measured after 16 weeks treatment. The protein level of WT1, nephrin and vitamin D receptor (VDR) was examined by Western blotting and immunohistochemical staining. There were no notable changes in blood ...Continue Reading

References

Apr 3, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M R HausslerP W Jurutka
May 16, 2003·JAMA : the Journal of the American Medical Association·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Nov 6, 2003·American Journal of Physiology. Renal Physiology·Alexander KuhlmannKerstin Amann
Mar 31, 2006·The New England Journal of Medicine·Karl TryggvasonJorma Wartiovaara
Nov 24, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jin TianDick de Zeeuw
Oct 12, 2007·Kidney International·Z ZhangY C Li
Feb 19, 2008·Diabetic Medicine : a Journal of the British Diabetic Association·J A SugdenA D Struthers
Apr 26, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Cheuk-Chun SzetoPhilip Kam-Tao Li
Sep 25, 2008·Kidney International·Michael FreundlichBernardo Rodriguez-Iturbe
Oct 8, 2008·Proceedings of the National Academy of Sciences of the United States of America·Zhongyi ZhangYan Chun Li
Jul 15, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Steven FishbaneNicole Durie
Aug 8, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Daisuke WatanabeKazue Takano
Nov 20, 2009·Kidney International·Peter Mundel, Jochen Reiser
Aug 10, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Michael S K WongPaul M Vanhoutte
Sep 10, 2010·International Journal of Medical Sciences·Min-shu ZouHong-tao Xu
Oct 13, 2010·Hypertension·Anand Vaidya, John P Forman
Nov 12, 2010·Current Diabetes Reviews·Yan Chun Li
Oct 25, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Li-Jun LiuHai-Yan Wang
Jan 10, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Jun ChengJianghua Chen
Nov 6, 2012·Journal of the American Society of Nephrology : JASN·Youli WangYan Chun Li
Feb 7, 2013·The American Journal of Pathology·Ramon SonneveldTom Nijenhuis
Oct 9, 2014·Molecular and Cellular Biochemistry·Xiaoliang ZhangMin Zhou
Dec 30, 2014·Journal of the American Society of Hypertension : JASH·James W LohrPradeep Arora
Dec 23, 2015·Journal of Endocrinological Investigation·X DengM Shen

❮ Previous
Next ❯

Citations

Feb 27, 2020·International Journal of Hypertension·Yuejia DingJunping Zhang
Jan 4, 2021·Advances in Medical Sciences·Virna Margarita Martín GiménezWalter Manucha

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Related Papers

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
Ling WangYu Yang
Hypertension Research : Official Journal of the Japanese Society of Hypertension
Tatsuhiko AzegamiHiroshi Itoh
Biochemical and Biophysical Research Communications
Feng GuoGuijun Qin
© 2022 Meta ULC. All rights reserved