Protective effect of carbon monoxide inhalation on lung injury after hemorrhagic shock/resuscitation in rats

The Journal of Trauma
Fumitoshi KanagawaKiyoshi Morita

Abstract

Hemorrhagic shock and resuscitation (HSR) induces pulmonary inflammation that leads to acute lung injury. Carbon monoxide (CO), a by-product of heme catalysis, was shown to have potent cytoprotective and anti-inflammatory effects. The aim of this study was to examine the effects of CO inhalation at low concentration on lung injury induced by HSR in rats. Rats were subjected to HSR by bleeding to achieve mean arterial pressure of 30 mm Hg for 60 minutes followed by resuscitation with shed blood and saline as needed to restore blood pressure. HSR animals were either maintained in room air or were exposed to CO at 250 ppm for 1 hour before and 3 hours after HSR. HSR caused an increase in the DNA binding activity of nuclear factor-kappaB and activator protein-1 in the lung followed by the up-regulation of pulmonary gene expression of tumor necrosis factor-alpha, inducible nitric oxide synthase, and interleukin (IL)-10. HSR also resulted in an increase in myeloperoxidase activity and wet weight to dry weight ratio in the lung, and more prominent histopathologic changes including congestion, edema, cellular infiltration, and hemorrhage. In contrast, CO inhalation significantly ameliorated these inflammatory events as judged by fewer ...Continue Reading

References

Sep 9, 1998·The American Journal of Physiology·M E ReylandE K White
Oct 8, 1999·Journal of Applied Toxicology : JAT·R Von Burg
May 4, 2000·The New England Journal of Medicine·L B Ware, M A Matthay
Jul 24, 2001·Langenbeck's Archives of Surgery·C Hierholzer, T R Billiar
Sep 10, 2002·Surgery·Rachel G KhadarooOri D Rotstein
Nov 22, 2002·American Journal of Respiratory Cell and Molecular Biology·Judit K SaradyAugustine M K Choi
Jul 5, 2003·Circulation Research·James E ClarkRoberto Motterlini
Jul 15, 2003·The Journal of Biological Chemistry·Danielle MorseAugustine M K Choi
Jan 27, 2004·The Journal of Pathology·Madhav Bhatia, Shabbir Moochhala
Jan 31, 2004·Shock·Kyoichiro MaeshimaShigeru Sassa
Feb 11, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Haralambos Gavras
Feb 21, 2004·Critical Care : the Official Journal of the Critical Care Forum·Gavin D PerkinsFang Gao
Feb 27, 2004·Respiratory Care Clinics of North America·Herbert P WiedemannJohn J Komara
Mar 6, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Judit K SaradyLeo E Otterbein
May 15, 2004·American Journal of Respiratory and Critical Care Medicine·Tamás DolinayAugustine M K Choi
May 26, 2004·Biochimica Et Biophysica Acta·Christian P SchneiderIrshad H Chaudry
Nov 24, 2004·American Journal of Respiratory and Critical Care Medicine·Florian B MayrBernd Jilma
May 18, 2005·Biochemical Pharmacology·Kyoichiro MaeshimaKiyoshi Morita
Jan 13, 2006·Annual Review of Pharmacology and Toxicology·Hong Pyo KimAugustine M K Choi
May 23, 2006·Immunity·Martin BilbanLeo E Otterbein
Jul 11, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A NakaoN Murase
Sep 27, 2006·The Journal of Experimental Medicine·Kiichi NakahiraAugustine M K Choi
Aug 23, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J KohmotoK R McCurry
Sep 12, 2007·Antioxidants & Redox Signaling·Stefan W RyterAugustine M K Choi
Nov 18, 2008·Cytokine·Philipp KobbeHans-Christoph Pape
Jan 30, 2009·Journal of Clinical Biochemistry and Nutrition·Atsunori NakaoKenneth R McCurry
Jan 30, 2009·Journal of Clinical Biochemistry and Nutrition·Toru TakahashiKiyoshi Morita
Feb 3, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·P KobbeH-C Pape
Mar 20, 2009·The New England Journal of Medicine·Lindell K Weaver

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Citations

Nov 10, 2011·Critical Care Medicine·Joslyn M AlbrightElizabeth J Kovacs
Jan 1, 2013·Oxidative Medicine and Cellular Longevity·Melissa KnauertPatty J Lee
Oct 8, 2011·The Science of the Total Environment·Yebin TaoWei Huang
Jun 26, 2014·Acta Anaesthesiologica Scandinavica·T K NielsenA Granfeldt
Apr 23, 2015·Critical Care : the Official Journal of the Critical Care Forum·Håkon HaugaaMichael R Pinsky
Dec 19, 2014·Journal of Burn Care & Research : Official Publication of the American Burn Association·Jan-Philipp StrompsNorbert Pallua
Apr 13, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Stephanie SchulzDavid K Stevenson
Apr 17, 2019·Experimental and Therapeutic Medicine·Yuta KumadaHiroshi Morimatsu
Nov 10, 2012·Molecular Medicine Reports·Susumu KawanishiKiyoshi Morita
Sep 1, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Laura E FredenburghClaude A Piantadosi

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