Protective effect of ceftriaxone against the nephrotoxicity of isepamicin administered once daily in rats

Biological & Pharmaceutical Bulletin
Y YoshiyamaM Kanke

Abstract

The protective effect of ceftriaxone on isepamicin-induced nephrotoxicity was investigated. For 14 d, Wistar rats were administered either ceftriaxone 100 mg/kg intraperitoneally, isepamicin 300 mg/kg subcutaneously, or ceftriaxone isepamicin in combination. The animals given 300 mg/kg of isepamicin showed a significant increase in urine NAG (N-acetyl-beta-D-glucosaminidase) levels as compared with the control animals which received saline (p<0.01). However, the increase in NAG level was markedly less when isepamicin was administered in combination with ceftriaxone (p<0.01). Ceftriaxone alone had no effect on urine NAG activity. Serum creatinine levels were significantly higher in animals treated with isepamicin alone than in control animals (p<0.01) or animals receiving the isepamicin ceftriaxone combination (p<0.01). After 14 d of treatment, ceftriaxone had not accumulated in renal tissue, but it did reduce the renal intracortical accumulation of isepamicin (p<0.01). Histopathologically, ceftriaxone induced very few cellular alterations and considerably reduced the manifestation of typical signs of isepamicin nephrotoxicity. This investigation demonstrates that ceftriaxone protects animals against isepamicin-induced nephrotox...Continue Reading

Citations

Feb 25, 2005·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Yuji YoshiyamaMotoko Kanke
Dec 16, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Mohamed M Abdel-DaimAbdelazim Ibrahim
May 9, 2002·Biological & Pharmaceutical Bulletin·Tomoko YazakiMotoko Kanke
Jan 24, 2002·Current Opinion in Critical Care·D Beauchamp, G Labrecque
Apr 1, 2019·Environmental Science and Pollution Research International·Mohamed M Abdel-DaimSimona G Bungau

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