PMID: 2117463Aug 1, 1990Paper

Protective effect of chorionic gonadotropin on DMBA-induced mammary carcinogenesis

British Journal of Cancer
I H RussoJ Russo

Abstract

The effect of the placental hormone chorionic gonadotropin (hCG) on 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumours was studied in young virgin Sprague-Dawley rats. This hormone when administered at a dose of 100 IU day-1 does not induce toxic effects, measured as alterations in body weight or weight of endocrine organs, and has a reversible effect on oestrous cycle. The lack of toxicity and the fact that hCG treatment terminated prior to administration of the chemical carcinogen DMBA protects the mammary gland from malignant transformation, led us to test the effect of hCG treatment on DMBA-initiated mammary tumours. Fifty day-old virgin Sprague-Dawley rats received intragastrically 8 mg DMBA per 100 g body weight and were divided into two groups: group I animals were treated with DMBA only and group II received DMBA at age 50 and in addition, a daily intraperitoneal injection of 100 IU hCG for days 21-81 post carcinogen administration. Tumorigenic response was evaluated by biweekly palpation of all animals and by complete autopsy 24 weeks after DMBA treatment. Group I animals developed an incidence of 100% of both tumours and adenocarcinomas. Group II animals developed a significantly lower incidence of tumours ...Continue Reading

Citations

Jan 1, 1994·In Vitro Cellular & Developmental Biology. Animal·M V AlvaradoI H Russo
Aug 28, 2009·Molecular Human Reproduction·Nafis A Rahman, C V Rao
Nov 20, 2002·Biological Chemistry·Davide BisacchiUlrich Pfeffer
Feb 14, 2009·Endocrine·Lakshmanaswamy RajkumarHuyen Duong
Aug 2, 2011·Journal of Mammary Gland Biology and Neoplasia·Irma H Russo, Jose Russo
Oct 8, 2011·International Journal of Immunopathology and Pharmacology·Manuela IezziF Cavallo
Aug 20, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Angiolo GadducciStefania Cosio
Mar 27, 2009·Experimental & Molecular Medicine·Kyoungsook ParkJean Chinock Kim Rim
Sep 1, 1995·Human Nature : an Interdisciplinary Biosocial Perspective·K Coe, L B Steadman
Sep 1, 1996·Environmental Health Perspectives·I H Russo, J Russo
Jan 1, 1995·Journal of Cellular Biochemistry. Supplement·J Russo, I H Russo
Nov 26, 2009·Cancer Prevention Research·Herbert I JacobsonThomas T Andersen

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