Protective Effect of Cleistocalyx nervosum var. paniala Fruit Extract against Oxidative Renal Damage Caused by Cadmium

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Warut PoontaweeO Wongmekiat

Abstract

Cadmium nephrotoxicity is a serious environmental health problem as it will eventually end up with end stage renal disease. The pathobiochemical mechanism of this toxic heavy metal is related to oxidative stress. This study investigated whether Cleistocalyx nervosum var. paniala fruit extract (CNFE) could protect the kidney against oxidative injury caused by cadmium. Initial analysis of the extract revealed antioxidant abilities and high levels of polyphenols, particularly catechin. Its potential renal benefits was further explored in rats treated with vehicle, CNFE, cadmium (2 mg/kg), and cadmium plus CNFE (0.5, 1, 2 g/kg) for four weeks. Oxidative renal injury was developed after cadmium exposure as evidenced by blood urea nitrogen and creatinine retention, glomerular filtration reduction, renal structural damage, together with increased nitric oxide and malondialdehyde, but decreased antioxidant thiols, superoxide dismutase, and catalase in renal tissues. Cadmium-induced nephrotoxicity was diminished in rats supplemented with CNFE, particularly at the doses of 1 and 2 g/kg. It is concluded that CNFE is able to protect against the progression of cadmium nephrotoxicity, mostly via its antioxidant power. The results also point ...Continue Reading

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Citations

Mar 21, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Monruedee SukprasansapTewin Tencomnao
Jan 23, 2018·Naunyn-Schmiedeberg's Archives of Pharmacology·Orawan WongmekiatAnongporn Kobroob
Feb 3, 2018·Pharmacology·Katsuhito NagaiHiroki Konishi
Nov 19, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Giang Nam PhamHieu Nguyen-Ngoc

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Methods Mentioned

BETA
MDA
urine collections
Assay

Software Mentioned

SPSS

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