Protective effect of coenzyme Q10 against bisphenol-A-induced toxicity in the rat testes

Toxicology and Industrial Health
Özay GüleşÜlker Eren

Abstract

The present study was conducted to investigate the antioxidant, histomorphometric, histochemical, immunohistochemical, biochemical, and cytological effects of coenzyme Q10 (CoQ10) against bisphenol-A (BPA)-induced testicular toxicity in rats. A total of 40 adult male Wistar rats were divided into five equal groups. The control group remained untreated. The vehicle control group was administered corn oil (2 ml/kg/day), the BPA group was given BPA (100 mg/kg/day), the CoQ10 group was supplemented with CoQ10 (10 mg/kg/day), and the rats in the CoQ10-BPA group received CoQ10 (10 mg/kg/day) followed by BPA (100 mg/kg/day) 1 h later. The treatments were administered by oral gavage for 14 days. Results showed that the seminiferous tubule diameters (STDs) and seminiferous epithelium heights (SEHs) at stages VII-VIII and XII-XIV, number of undifferentiated embryonic cell transcription factor-1 (UTF-1) positive cells per tubule, UTF-1 positive tubules (%), plasma glutathione (GSH), and serum superoxide dismutase activities, testicular GSH activity and sperm viability (%) decreased whereas the number of terminal dUTP nick end labeling (TUNEL) positive cells per tubule, TUNEL positive tubules (%), testicular and serum malondialdehyde (MDA)...Continue Reading

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Citations

Jul 2, 2020·Journal of Biochemical and Molecular Toxicology·Chittaranjan SahuGopabandhu Jena
Jun 30, 2021·Ecotoxicology and Environmental Safety·Yuan LiuXiangchen Li

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Methods Mentioned

BETA
MDA
sedation
ELISA

Software Mentioned

SPSS
Win Plus
Leica Q - Win Standard

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