Protective effect of cultured bear bile powder against dimethylnitrosamine-induced hepatic fibrosis in rats

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Min ZhengYue-Ming Ma

Abstract

Natural bear bile has been used for liver disease in East Asia for thousands of years. However, its use has restrictions. In the current study, the therapeutic effects and potential mechanisms of cultured bear bile powder (CBBP) against hepatic fibrosis were evaluated in a dimethylnitrosamine (DMN)-induced rat model. CBBP treatment significantly improved DMN-induced hepatic necrosis and inflammatory infiltration. Additionally, CBBP remarkably alleviated the increased hepatic collagen content and expression of alpha-smooth muscle actin. Serum metabolomics revealed that 14 serum metabolites, including docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) were decreased in DMN-treated rats, which was reversed by CBBP. Pathway analyses revealed that the main metabolic pathways affected by CBBP were related to fatty acid biosynthesis and metabolism, and biosynthesis of unsaturated fatty acids. EPA and DHA are ligands of peroxisome proliferator activated receptors (PPARs). CBBP treatment significantly stimulated liver mRNA and protein expression of PPARα and PPARγ. CBBP also markedly increased liver expression of PPARα target genes, which are involved in fatty acid β-oxidation, and down-regulated IL-6, a downstream inflammatory ...Continue Reading

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Citations

Sep 16, 2020·Analytical Methods : Advancing Methods and Applications·Tianming WangYueming Ma
Jun 26, 2021·Drug Design, Development and Therapy·Jingjing LiJianye Wu

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