Protective effect of diallylsulphide against mercuric chloride-induced hepatic injury in rats

Human & Experimental Toxicology
Sabah Ansar, M Iqbal

Abstract

The present study was undertaken to evaluate the effect of diallylsulphide (DAS) against mercuric chloride (HgCl2)-induced oxidative stress in rat livers. Rats were randomly divided into four groups of six rats each and exposed to HgCl2 (50 mg/kg/body weight (b.w.)) intraperitoneally and/or DAS (200 mg/kg/b.w.) by gavage. HgCl2 administration enhanced alanine aminotransferase (AST) and aspartate aminotransferase (ALT) levels (p < 0.05) with reduction in the levels of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px). However, treatment with DAS markedly attenuated HgCl2-induced biochemical alterations in liver and serum transaminases (AST and ALT; p < 0.05). Further, biochemical results were confirmed by histopathological changes as compared to HgCl2-intoxicated rats. Histopathology of liver also showed that administration of DAS significantly reduced the damage generated by HgCl2 The present study suggests that DAS shows antioxidant activity and plays a protective role against mercury-induced oxidative damage in the rat livers.

References

Jan 1, 1992·Nutrition and Cancer·C IpG S Stoewsand
Mar 1, 1992·Toxicology and Applied Pharmacology·M E Blazka, Z A Shaikh
Jan 1, 1990·Methods in Enzymology·H H Draper, M Hadley
Jan 31, 1972·Biochemical and Biophysical Research Communications·M NishikimiK Yagi
Jan 1, 1984·Methods in Enzymology·H Aebi
Jan 1, 1995·Free Radical Biology & Medicine·G Girardi, M M Elías
May 1, 1996·Biological Trace Element Research·Y L HuangT H Lin
Jan 1, 1996·Advances in Experimental Medicine and Biology·M J Wargovich, N Uda
May 6, 1999·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·C P SiegersR Pentz
Mar 13, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·L M AntunesN de L Bianchi
Oct 16, 2001·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·M MahboobA T Khan
Jan 16, 2002·Cancer Letters·Yogeshwer Shukla, Pankaj Taneja
Dec 24, 2004·Critical Reviews in Food Science and Nutrition·Farhath KhanumK R Viswanathan
Feb 3, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Göksel SenerGülden Z Omurtag
May 25, 2011·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Piotr SuraMaria Wróbel
Aug 9, 2011·Mutation Research·Gustavo Rafael Mazzaron BarcelosFernando Barbosa Júnior
Oct 12, 2012·Annals of the New York Academy of Sciences·Hsiao-Chi WangLee-Yan Sheen
Jun 4, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S Ansar
Nov 1, 2013·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Mahmut KarapehlivanMusa Karaman
Apr 23, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mohamed S OthmanAhmed E Abdel Moneim
Nov 19, 2014·Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer·Yu DengTianyao Yang

❮ Previous
Next ❯

Citations

Mar 24, 2018·Journal of Basic and Clinical Physiology and Pharmacology·Sunny O AbarikwuChigozie L Onuah
Oct 3, 2018·Advanced Pharmaceutical Bulletin·Velid Unsal
Feb 26, 2019·Oxidative Medicine and Cellular Longevity·Dong-Dong WuXin-Ying Ji
Aug 24, 2019·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Cuneyt CaglayanMuhammet Bahaeddin Dortbudak
Nov 4, 2020·Journal of Agricultural and Food Chemistry·Jinxin XieRi-Yuan Tang

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.