Protective effect of dietary long-chain n-3 polyunsaturated fatty acids on bone loss in gonad-intact middle-aged male rats

The British Journal of Nutrition
Chwan-Li ShenB A Watkins

Abstract

This study evaluated the effect of a fat blend containing long-chain (LC) n-3 PUFA on bone mineral density (BMD) and bone metabolism in gonad-intact middle-aged male rats (12 months old, n 28). Seven rats were killed on day 0 of dietary intervention to determine the baseline BMD. The remaining rats (seven per group) were fed a diet with one of the following dietary lipid treatments (g/kg diet): 167 g safflower oil + 33 g menhaden oil (N6 + N3 diet, control), 200 g safflower oil (N6 diet, almost devoid of LC n-3 PUFA), or 190 g menhaden oil + 10 g corn oil (N3 diet, rich in LC n-3 PUFA) for 20 weeks. After 20 weeks, all dietary treatment groups had a lower BMD compared with the baseline reference. However, rats fed the N3 diet had the highest bone mineral content and cortical + subcortical BMD compared with those fed the N6 and control N6 + N3 diet. Compared with the control (N6 + N3) group, rats fed the N3 diet had higher values for serum insulin-like growth factor-I, parathyroid hormone, 1,25-(OH)2 vitamin D3 and bone-specific alkaline phosphatase activity, but lower bone NO production and urinary Ca, whereas rats fed the N6 diet had higher bone prostaglandin E2 production and serum pyridinoline. These findings indicate a prot...Continue Reading

References

Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·I MacIntyreJ R Vane
Jul 10, 1987·Science·J W Rowe, R L Kahn
Jul 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S H RalstonN Benjamin
Dec 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·G R Mundy
Nov 1, 1994·Toxicologic Pathology·W E HoffmannP F Solter
Feb 1, 1994·Prostaglandins, Leukotrienes, and Essential Fatty Acids·K SakaguchiS Murota
Jan 1, 1996·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P AmmannJ P Bonjour
Sep 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·B A WatkinsM F Seifert
Feb 5, 1999·Aging : Clinical and Experimental Research·M C KrugerD H van Papendorp
Jul 15, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Y LiB A Watkins
Aug 7, 1999·Annals of Nutrition & Metabolism·A P SimopoulosN Salem
Sep 15, 1999·Calcified Tissue International·A ShiraishiE Ogata
Mar 16, 2000·Prostaglandins, Leukotrienes, and Essential Fatty Acids·C K SchlemmerM C Kruger
Apr 15, 2000·Nature·P G Kopelman
Jun 28, 2000·Proceedings of the National Academy of Sciences of the United States of America·R J van't HofS H Ralston
Aug 15, 2001·Bone·L WangD N Kalu
Apr 18, 2003·Endocrinology and Metabolism Clinics of North America·Lawrence G Raisz, Gideon A Rodan
Jun 12, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Bruce A WatkinsShulin Feng
Jul 12, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Dongxu SunGabriel Fernandes
Aug 31, 2004·Lab Animal·Nancy L Nadon
Sep 28, 2004·The American Journal of Clinical Nutrition·Hope A Weiler, Marlena C Kruger
Apr 9, 2005·The American Journal of Clinical Nutrition·Lauren A WeissDenise von Mühlen
Apr 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amy R WeatherillDaniel H Hwang
Jul 27, 2005·The Journal of Nutritional Biochemistry·Bruce A WatkinsMark F Seifert
Aug 1, 1990·Clinical Biomechanics·J C HouR J Barnard

❮ Previous
Next ❯

Citations

Jul 17, 2013·Current Osteoporosis Reports·Kelsey M ManganoMarian T Hannan
May 5, 2011·Journal of Toxicology and Environmental Health. Part a·Jianmin ChenLilian U Thompson
Aug 21, 2010·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Beatrice Y Y LauDavid W L Ma
Oct 29, 2010·The American Journal of Clinical Nutrition·Tonya S OrchardRebecca D Jackson
Dec 5, 2013·Physiological Reports·Mona A Ahmed, Abeer A Abd El Samad
May 28, 2013·Calcified Tissue International·Kiyoko NawataToshitsugu Sugimoto
Dec 18, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C-L ShenJ-S Wang
Apr 16, 2010·Journal of Bone and Mineral Metabolism·Jameela BanuGabriel Fernandes
Jul 6, 2010·Progress in Lipid Research·M C KrugerH Weiler
Aug 19, 2008·The Journal of Nutritional Biochemistry·Beatrice Y Y LauDavid W L Ma
Sep 29, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Tonya S OrchardRebecca D Jackson
Sep 12, 2006·The Journal of Nutritional Biochemistry·Arunabh BhattacharyaGabriel Fernandes
May 6, 2014·The Journal of Surgical Research·Erica M FallonMark Puder
Apr 4, 2015·Progress in Lipid Research·Fabien WauquierYohann Wittrant
Oct 31, 2006·Journal of Bone and Mineral Metabolism·Chwan-Li ShenXingjia Wang
Sep 7, 2019·Canadian Journal of Physiology and Pharmacology·Aleksandra ArsicVesna Vucic
Dec 5, 2019·Cell Proliferation·Minyue BaoLing Ye
Jun 18, 2020·Journal of Food Biochemistry·Tanu Sharma, Chandi C Mandal
Feb 6, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B-J KimJ-M Koh
Mar 25, 2009·Experimental Biology and Medicine·Beatrice Y Y LauDavid W L Ma
Jun 25, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T KurodaM Shiraki
Jul 3, 2021·International Journal of Molecular Sciences·Jose M Romero-MárquezJosé L Quiles

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Related Papers

Prostaglandins, Leukotrienes, and Essential Fatty Acids
M C Kruger, Linda M Schollum
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Dongxu SunGabriel Fernandes
© 2021 Meta ULC. All rights reserved