Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Lingli ZhengJinyong Peng

Abstract

Our previous works showed that dioscin, a natural product, could protect liver from acute liver damages induced by dimethylnitrosamine, ethanol, carbon tetrachloride and acetaminophen. However, the effect of dioscin on thioacetamide (TAA)-induced acute liver injury still remained unknown. The purpose of this study was to investigate whether dioscin confers a protective effect against TAA-induced acute liver injury in rats and mice. The results showed that dioscin decreased the serum levels of ALT, AST, and rehabilitated histopathological changes compared with the model groups. In addition, dioscin obviously increased the levels of GSH, GSH-Px, SOD, and significantly reduced MDA levels compared with the model groups. Mechanistic study showed that dioscin significantly up-regulated the expression levels of FXR, p-AMPKα, and then increased the expression levels of Nrf2, HO-1, NQO-1, GCLM and GST. Furthermore, dioscin obviously down-regulated the expression levels of NF-κB (p65), ICAM-1, HMGB1, COX-2, TNF-α, IL-1β and IL-6. Taken together, dioscin showed protective effect against TAA-induced acute liver injuries in rats and mice and the effects might be obtained through inhibiting oxidative stress and inflammation via FXR/AMPK sign...Continue Reading

Citations

Sep 12, 2018·Hepatology Communications·Harriet GaskellNatalia Nieto
Jan 2, 2019·BioMed Research International·Longfei YangTonghui Ma
Sep 13, 2019·BioMed Research International·Longfei YangLufei Wang
Sep 5, 2018·Current Clinical Pharmacology·Marwa HassanHend M Abd Elghany
Jan 1, 2021·Toxicology and Applied Pharmacology·Lu YuFengxia Zhang
Oct 24, 2020·International Journal of Molecular Sciences·Anna Maria CzarneckaMagdalena Zielińska
Apr 26, 2021·Pharmacology & Therapeutics·Nana YanFrank J Gonzalez
Jun 1, 2021·Frontiers in Immunology·Eduardo Duarte-SilvaChristina Alves Peixoto
Jul 26, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Lina KongQiang Meng
Jul 13, 2021·Prostaglandins & Other Lipid Mediators·Izumi TsukayamaToshiko Suzuki-Yamamoto

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Aneurysm

Aneurysm refers to a bulge of the wall or lining of a vessel commonly occurring in the blood vessels at the base of the septum or within the aorta. In the heart, it usually arises from a patch of weakened tissue in a ventricular wall, which swells into a bubble filled with blood. Discover the latest research on cardiac aneurysm here.

Aortic Aneurysm

An aortic aneurysm is the weakening and bulging of the blood vessel wall in the aorta. This causes dilatation of the aorta, which is usually asymptomatic but carries the risk of rupture and hemorrhage. Find the latest research on aortic aneurysms here.