PMID: 8609456Feb 1, 1996Paper

Protective effect of dipyridamole against lethality and lipid peroxidation in liver and spleen of the ddY mouse after whole-body irradiation

International Journal of Radiation Biology
T UedaT Hishida

Abstract

The effects of dipyridamole on radiation damage in the mouse were investigated. Dipyridamole (i.p. 2 mg/mouse) administered 1 h before exposure, protected against gamma-irradiation. Pretreatment significantly decreased the death rate at 30 days from 89 to 33% (p<0.001) after 9 Gy whole-body irradiation. LD50 at 30 days was increased from 6.67 to 7.65 Gy in the dipyridamole pretreated group. The level of thiobarbituric acid reactive substances (TBARS) in the liver and spleen, a measure of free radical initiated liver peroxidation, increased 155, 193, 195, and 236% of control (without irradiation) in liver, and 132, 146, 168, and 276% of control (without irradiation) in spleen on days 2, 4, 7, and 10 after 9 Gy of whole-body irradiation respectively. The TBARS levels in both liver and spleen 2 days after irradiation were reduced to 73 +/- 7 and 60 +/- 19% respectively after dipyridamole treatment (2 mg/mouse, i.p. injection 1 h before exposure). In electron microscopic studies, mitochondria and endoplasmic reticulum in the irradiated mouse liver were swollen, but otherwise appeared normal after dipyridamole treatment. These results suggest that dipyridamole has a protective effect on animal survival 30 days after 60Co gamma-irrad...Continue Reading

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Citations

Sep 21, 2000·Proceedings of the Society for Experimental Biology and Medicine·M Karbownik, R J Reiter
Jan 24, 2006·Preparative Biochemistry & Biotechnology·Eui-Chul ParkEun-Mi Park
Aug 22, 2007·The British Journal of Radiology·W ZhaoM E Robbins
Jun 19, 2004·International Journal of Radiation Biology·M E C Robbins, W Zhao
Mar 31, 2007·Seminars in Radiation Oncology·John E Moulder, Eric P Cohen
Jun 9, 2004·International Journal of Radiation Oncology, Biology, Physics· VijayalaxmiCharles R Thomas
Apr 20, 2004·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Ulko UndegerNurçen Baçaran
Dec 19, 2012·Medical Hypotheses·Samuel R Cohen, Eric P Cohen
Jun 20, 2017·International Journal of Radiation Biology·Kimihiko Sugaya
Apr 16, 1998·The Journal of Biological Chemistry·E P RogakouW M Bonner
Sep 20, 2002·Journal of Radiation Research·Keiko SuzukiHiroshi Ishihara
May 31, 2007·Journal of Radiation Research·Won-Il JeongKyu-Shik Jeong
Jun 29, 2021·Free Radical Research·Rahul CheckerSantosh K Sandur

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