Protective effect of early placement of nasogastric tube with solid dilator on tissue damage and stricture formation after caustic esophageal burns in rabbits

Journal of Pediatric Surgery
Victor DefagóEduardo Cuestas

Abstract

The ingestion of caustic substances remains an important public health issue worldwide. Children represent 80% of the ingestion injury population globally. Accidental alkaline material accounts for most caustic ingestions. There is no conclusive evidence of tissue damage and stricture protection of a nasogastric-tube with a solid dilator in the literature, therefore it was hypothesized that early intraesophageal tube placement does not cause additional histopathologic damage and prevents strictures. An exploratory study on experimental caustic esophageal burns in a rabbit model was designed. In the treated group a silicone tube was placed immediately after causing the burns, while the untreated group followed the natural course of the burn. On the twenty-secondday, an esophagectomy was performed on all animals for microscopic (Histopathologic Damage Score and Stenosis Index) and macroscopic analysis. Forty animals were randomly divided into two groups. The Histopathologic Damage Score was 3.7±1.1 in the treated group versus 3.9±1.2 in the untreated group (p=.9690). The Stenosis Index was 0.6±0.1 in treated rabbits versus 2.3±0.2 in untreated (p<.0001). The early placement of an intraesophageal tube with solid dilator prevents s...Continue Reading

References

Feb 1, 1976·The Journal of Surgical Research·H M Reyes, J L Hill
Jan 1, 1992·The American Journal of Gastroenterology·V V Gumaste, P B Dave
Feb 1, 1989·Journal of Pediatric Surgery·F A WijburgN A Urbanus
Nov 1, 1996·Journal of Pediatric Surgery·O MutafA Arikan
Jul 9, 1998·The Journal of Surgical Research·R H HuR G Tompkins
Mar 3, 1999·Journal of Pediatric Surgery·M Bingöl-KologluA Hiçsönmez
Apr 22, 1999·Journal of Pediatric Surgery·E GünelI Akillioğlu
Feb 15, 2001·São Paulo Medical Journal = Revista Paulista De Medicina·R C Mamede, F V de Mello Filho
Aug 29, 2003·The Journal of Surgical Research·Melih TugayZafer Utkan
Feb 22, 2005·The American Journal of Sports Medicine·Curtis A HansonLaurence E Dahners
Sep 6, 2005·The American Journal of Emergency Medicine·William A WatsonKathleen M Wruk
Jul 15, 2006·International Journal of Pediatric Otorhinolaryngology·Akile Sarioglu-BukeUgur Koltuksuz
May 9, 2007·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Jessica A Fulton, Robert S Hoffman
Sep 10, 2008·Journal of Pediatric Surgery·Mohammad OsmanD Neil Granger
Jun 23, 2009·Current Opinion in Pediatrics·Marsha Kay, Robert Wyllie
May 11, 2010·Bulletin of the World Health Organization·Sandro ContiniCarmelo Scarpignato
Nov 3, 2010·International Journal of Dermatology·Mohammad Reza NamaziRobert A Schwartz
Jun 17, 2011·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·A KapisizA C Basaklar
Aug 20, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Carol A de la Motte
Sep 14, 2011·Expert Review of Gastroenterology & Hepatology·Mortada Elshabrawi, Hassan H A-Kader
Jul 11, 2013·World Journal of Gastroenterology : WJG·Sandro Contini, Carmelo Scarpignato

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved