Protective effect of erythropoietin pretreatment in testicular ischemia-reperfusion injury in rats

Journal of Pediatric Surgery
Bekir Ugur ErgurGuven Erbil

Abstract

This study was designed to investigate the effects of recombinant erythropoietin (EPO), a hormone widely used for treatment of uremic anemia, in rats subjected to testicular ischemia and reperfusion (I/R). Thirty-five male rats were divided into the following: control, sham operated, ischemia (I), I/R, and I/R + EPO groups. In the I group, 2 hours of left unilateral testicular torsion were performed, and in the I/R and I/R + EPO groups, an additional 2 hours of testicular detorsions were performed. The I/R + EPO group was pretreated intraperitoneally with EPO (500 IU/kg) before reperfusion. Testicular tissue samples were examined for biochemical and histopathologic parameters. Apoptotic cells in all testes were detected by terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling technique and caspase 3 immunohistochemistry. At histopathologic examination, ischemic changes in primary spermatocytes were noted in all torted testes. Cellular damage and apoptosis were more severe in ischemic groups than the EPO-pretreated group. There were statistically significant differences in tissue biochemical parameters in the I and I/R groups compared with the I/R + EPO group. The results of the present study suggest that EPO exe...Continue Reading

References

Apr 1, 1990·Pediatric Research·C PalmerJ Towfighi
Aug 1, 1993·Biology of Reproduction·T T Turner, K J Brown
Jan 4, 1998·Biology of Reproduction·T T TurnerL W Wilson
Feb 13, 1999·Kidney International·R G CarliniE Bellorin-Font
Aug 11, 2000·European Journal of Pharmacology·G CalapaiM Buemi
Mar 31, 2004·Molecular Aspects of Medicine·Danilo Wilhelm FilhoAlberto Boveris
Jul 31, 2004·Journal of the American Society of Nephrology : JASN·Edward J SharplesMuhammad M Yaqoob
Jan 6, 2005·JAMA : the Journal of the American Medical Association·Kenneth MaieseZhao Zhong Chong
Mar 3, 2005·Pediatric Surgery International·Dinçer AvlanSelim Aksöyek
Jul 14, 2005·Fundamental & Clinical Pharmacology·M Joyeux-FaureC Ribuot
Nov 12, 2005·Pediatric Surgery International·Jorge G MogilnerIgor Sukhotnik
Dec 20, 2005·Urology·Amirali Hassanzadeh SalmasiAhmad Reza Dehpour
Jan 18, 2006·The Journal of Surgical Research·Ali CayOrhan Değer
Mar 25, 2006·Pediatric Surgery International·Ayten GeziciHanifi Okur
Sep 1, 2007·International Journal of Urology : Official Journal of the Japanese Urological Association·Bulent AkcoraEsin Atik

❮ Previous
Next ❯

Citations

Sep 18, 2009·Pediatric Surgery International·Vedat BakanFatma Inanç Tolun
Jul 16, 2008·International Urology and Nephrology·Burhan KöseoğluFatih Hizli
Nov 6, 2013·The Journal of Veterinary Medical Science·In-Ohk OuhPhil-Ok Koh
Nov 30, 2012·TheScientificWorldJournal·Seda OzbalZahide Cavdar
Apr 2, 2010·Biological Trace Element Research·Ajmal AhmadFakhrul Islam
Jul 3, 2015·Experimental and Therapeutic Medicine·Xian-Feng ZhaoY U Xu
Oct 27, 2009·Journal of Pediatric Surgery·Vedat BakanSenol Oztürk
Aug 13, 2011·The Journal of Investigative Dermatology·Claire DemiotJean-Michel Achard
Oct 9, 2008·Acta Anaesthesiologica Scandinavica·S Kapoor
Sep 25, 2012·Basic & Clinical Pharmacology & Toxicology·Zhitao JiangDapeng Jiang
Jul 23, 2013·International Immunopharmacology·Bo XuDa-peng Jiang
Oct 10, 2012·Journal of Pediatric Urology·Daniel G DaJustaLinda A Baker
Dec 30, 2017·Basic & Clinical Pharmacology & Toxicology·Aynur SahinYesim Tuncok
Jan 28, 2020·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·Betul YazğanMustafa Cihat Avunduk
Mar 1, 2019·International Journal of Molecular Sciences·Ning QuKou Sakabe
Jun 8, 2017·Experimental and Therapeutic Medicine·Ioannis D KostakisTheodoros Karatzas
Jun 2, 2017·Experimental and Therapeutic Medicine·Salvatore ArenaCarmelo Romeo
Feb 14, 2018·International Journal of Molecular Medicine·Li LiFulu Gao
Feb 8, 2021·Andrologia·Recep B DegirmentepeMustafa B Cekmen
Mar 5, 2021·Andrologia·Betul YazğanMustafa Cihat Avunduk

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis