Protective effect of forsythiaside A on lipopolysaccharide/d-galactosamine-induced liver injury

International Immunopharmacology
Chen-Wei PanZhen-Zhen Pan

Abstract

Forsythiaside A, an active constituent isolated from air-dried fruits of Forsythia suspensa, has been reported to have multiple pharmacological activities including anti-inflammatory, anti-oxidant, and antioxidant activities. In the present study, the hepatoprotective effect of forsythiaside A was investigated in lipopolysaccharide (LPS)/d-galactosamine (GalN)-induced acute liver injury in mice. Mice acute liver injury model was induced by LPS (50μg/kg)/GalN (800mg/kg). Forsythiaside A was administrated 1h prior to LPS/GalN exposure. The results showed that forsythiaside A attenuated hepatic pathological damage, malondialdehyde (MDA) content, and serum ALT, and AST levels induced by LPS/GalN. Moreover, forsythiaside A inhibited NF-κB activation, serum TNF-α and hepatic TNF-α levels induced by LPS/GalN. Furthermore, we found that forsythiaside A up-regulated the expression of Nrf2 and heme oxygenase-1. Our results showed that forsythiaside A protected against LPS/GalN-induced liver injury through activation of Nrf2 and inhibition of NF-κB activation.

References

Nov 1, 1992·Critical Care Medicine·B G HarbrechtR L Simmons
Jun 8, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T NakamaH Tsubouchi
Jul 9, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Takayuki MasakiHironobu Yoshimatsu
Sep 16, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Cheng JiNeil Kaplowitz
Sep 28, 2004·Diabetes·Anthony J G HanleyUNKNOWN insulin resistance atherosclerosis study
Apr 12, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Saadet TurksevenNader G Abraham
Apr 6, 2006·The Journal of Clinical Investigation·Rajesh K ThimmulappaShyam Biswal
Jul 12, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kazuki UedaMasao Ichinose
Feb 23, 2010·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Li ZhangJing-Yuan Wan
Jan 8, 2013·Pharmacology, Biochemistry, and Behavior·Hong-Mei WangAhsana-Dar Farooq
Nov 19, 2013·Biochemical Pharmacology·Chao-Fu ChangWilliam Durante
Nov 2, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J RaoL Lu

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Citations

Apr 28, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yi-Lian XieNai-Bin Yang
Mar 7, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiao-Tian ZhangTong Zhang
Sep 5, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhanglu DongMenghua Liu
Sep 22, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Yi GuoHai-Xiao Han
Aug 12, 2020·Medicinal Research Reviews·Lipeng WuBaiyi Lu
Jun 20, 2017·Pharmacological Reports : PR·Efrat Finkin-GronerMarta Weinstock
Jan 23, 2021·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Omnia S ErfanMarwa Abd El-Kader
Mar 1, 2018·Comprehensive Reviews in Food Science and Food Safety·Xiao MengHua-Bin Li
Feb 14, 2021·International Journal of Molecular Sciences·Kristiana M AmirovaMilen I Georgiev
May 25, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Lihong GongYunxia Li

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