Protective effect of fucosterol isolated from the edible brown algae, Ecklonia stolonifera and Eisenia bicyclis, on tert-butyl hydroperoxide- and tacrine-induced HepG2 cell injury

The Journal of Pharmacy and Pharmacology
Jae Sue ChoiHyun Ah Jung

Abstract

Fucosterol is the primary sterol found in brown algae. Recently, considerable interest has been generated regarding fucosterol due to its potential antioxidant, anti-inflammatory and antidiabetic effects. The aim of this study was to investigate the protective effects of fucosterol on tert-butyl hydroperoxide (t-BHP)- and tacrine-induced oxidative stress in HepG2 cells. Fucosterol by itself exhibited no cytotoxicity at concentrations below 100 μm by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay. The increased intracellular reactive oxygen species (ROS) and decreased glutathione levels observed in t-BHP- and tacrine-treated HepG2 cells were ameliorated by fucosterol pretreatment, indicating that the protective effects of fucosterol are mediated by the induction of cellular defence mechanisms against oxidative stress. Moreover, elevated alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in tacrine-treated mice were significantly reduced after oral administration of fucosterol. The hepatoprotective effects of fucosterol may occur via an increase in the hepatic level of glutathione and a decrease in ROS production, thereby preventing hepatic damage and the resultant increases in ALT...Continue Reading

References

Jun 11, 2002·Annual Review of Nutrition·Julie A Ross, Christine M Kasum
Dec 25, 2002·Free Radical Biology & Medicine·Carmela Loguercio, Alessandro Federico
Oct 17, 2003·Archives of Pharmacal Research·Sanghyun LeeKuk Hyun Shin
Jan 31, 2004·Phytochemistry·Ran XuSeiichi P T Matsuda
Apr 23, 2004·Biomedical Chromatography : BMC·D I Sánchez-MachadoJ López-Cervantes
Dec 15, 2004·Archives of Pharmacal Research·Yeon Sil LeeSanghyun Lee
Jun 23, 2005·Critical Reviews in Food Science and Nutrition·Paola VitaglioneVincenzo Fogliano
Feb 14, 2006·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M J M EzoulinF Massicot
May 7, 2008·The American Journal of Chinese Medicine·Kuo-Lung KuHui-Fen Liao
Aug 19, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Arumugam SathivelThiruvengadam Devaki
Jan 1, 1990·Neurochemistry International·C P Lebel, S C Bondy
Aug 1, 1999·Toxicology in Vitro : an International Journal Published in Association with BIBRA·R A OsseniJ M Warnet
Sep 3, 2010·Natural Product Research·S Sadish KumarV Gupta
Jan 1, 2001·Pharmaceutical Biology·K HostettmannC Terreaux
Jan 25, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Moumita Pal, M Ghosh
Apr 17, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Min-Cheol KangYou-Jin Jeon
Jun 19, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hyun Ah JungJae Sue Choi
Jan 1, 2010·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Ali A El Gamal
Mar 29, 2014·World Journal of Hepatology·Nancy Vargas-MendozaJosé A Morales-González

❮ Previous
Next ❯

Citations

Oct 1, 2016·Journal of Medicinal Food·Ok-Kyung KimWoojin Jun
Aug 31, 2016·International Journal of Food Sciences and Nutrition·Francesca D'AcunzoOrnella Ursini
Mar 16, 2017·Natural Product Reports·John W BluntMichèle R Prinsep
Oct 13, 2015·Journal of the Science of Food and Agriculture·Qudeer Ahmed AbdulJae Sue Choi
Sep 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Daniela Gabbia, Sara De Martin
Apr 11, 2020·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Md Abdul HannanIl Soo Moon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Kyung Jin LeeHye Gwang Jeong
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Yong Pil HwangHye Gwang Jeong
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Yong Pil HwangHye Gwang Jeong
© 2021 Meta ULC. All rights reserved