Protective effect of gallic acid against lindane induced toxicity in experimental rats

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Viswanadha Vijaya PadmaParamasivan Poornima


Lindane is an organochlorine pesticide that persists in the environment, bioaccumulate through food chain and has a risk of causing adverse effects to human health and the environment. It induces cell damage by producing free radicals and reactive oxygen species. The aim of the present study is to investigate the protective effect of gallic acid (a plant derived polyphenol) against lindane induced hepatic and renal toxicity in rats. Liver damage was assessed by hepatic serum marker enzymes like SGOT, SGPT and ALP and histopathological observation. Renal damage was observed by histopathological examination and serum markers like creatinine and urea. Treatment with lindane increased the levels of lipid peroxidation, serum marker enzyme activity with a concomitant decrease in GSH, CAT, SOD, GPx and GST. Histological alterations were also observed in kidney and liver tissue with lindane treatment. Co-treatment of gallic acid significantly prevented the lindane induced alterations in kidney and liver tissues with a decrease in LPO, serum marker enzyme activity and a significant increase in antioxidant levels. These results suggest that gallic acid has protective effect over lindane induced oxidative damage in rat liver and kidney.


Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Jan 1, 1990·Free Radical Biology & Medicine·L A VidelaV B Junqueira
Jan 1, 1990·Annual Review of Pharmacology and Toxicology·D J Reed
Dec 1, 1990·Bulletin of Environmental Contamination and Toxicology·L Nelson
Jan 1, 1989·Chemico-biological Interactions·M Comporti
Jan 1, 1987·Archives of Toxicology·H Kappus
Feb 1, 1986·The Australian Journal of Experimental Biology and Medical Science·S MathewP A Kurup
Feb 9, 1973·Science·J T RotruckW G Hoekstra
Jun 19, 1973·Biochemical and Biophysical Research Communications·M J PabstW B Jakoby
Dec 1, 1983·Toxicology Letters·I ThorupP Olsen
Jun 1, 1983·Biochemical Society Transactions·G W BurtonT F Slater
Oct 1, 1995·Archives of Biochemistry and Biophysics·N SalahC Rice-Evans
Jan 1, 1994·Advances in Experimental Medicine and Biology·M T Moslen
Oct 1, 1994·Toxicology and Applied Pharmacology·G B CorcoranR Buttyan
Oct 28, 1994·Biochemical and Biophysical Research Communications·M InoueY Yabu
Jan 5, 1996·Biochimica Et Biophysica Acta·H KawashimaS Shimizu
May 1, 1996·Heart & Lung : the Journal of Critical Care·M E KerrE J Monti
Jan 1, 1997·Environmental Research·B D BanerjeeA Ray
Jul 22, 1999·Toxicology Letters·B D BanerjeeA K Chakraborty
Dec 10, 1999·Journal of Agricultural and Food Chemistry·M P KähkönenM Heinonen
Jan 21, 2000·Free Radical Biology & Medicine·W Bors, C Michel
Sep 29, 2000·Pharmacology & Therapeutics·J Spychala
Feb 24, 2001·Free Radical Research·A S LiA J Davison
Apr 11, 2001·Free Radical Biology & Medicine·R Abu-Amsha CaccettaK D Croft
May 17, 2001·Reviews on Environmental Health·B D BanerjeeR S Ahmed
Jun 19, 2001·Journal of Inorganic Biochemistry·M J Hynes, M O Coinceanainn
Jan 24, 2002·Journal of Agricultural and Food Chemistry·Sopheak Son, Betty A Lewis
Jul 1, 1957·American Journal of Clinical Pathology·S REITMAN, S FRANKEL
Apr 1, 1960·The Journal of Clinical Investigation·S TAKAHARAE T NISHIMURA
Oct 7, 2003·Current Molecular Medicine·Irina Kessova, Arthur I Cederbaum

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